视网膜色素变性的眼底血流变化研究现状  

Research advances in fundus blood flow changes in retinitis pigmentosa

作　　者：殷晓贝[1] 李根林[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心,北京市眼科学与视觉科学重点实验室,北京市100730

出　　处：《眼科新进展》2015年第5期482-484,488,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81271046)~~

摘　　要：视网膜色素变性(retinitis pigmentosa,RP)是一种临床常见的遗传性致盲性眼底病,多由夜盲起病,经过几十年进行性视力下降致最终失明。其病理特点为原发性感光细胞凋亡长期发展最终导致视网膜色素上皮和内层视网膜结构及功能损伤。多个研究表明RP早期出现眼底血流减少。原因可能是原发性血管功能失调和血浆内皮素-1升高。目前有多种可有效评估视网膜血流情况的方法。针对改善眼底血流的治疗能够在一定程度上延缓RP病情的进展。对于眼底血流和RP关系的认识加深有助于寻找新的有效治疗RP的方法。Retinitis pigmentosa （RP） is a common hereditary fundus disease which starts with night blindness in teenage and eventually loses visual acuity after decades. It is characterised by primary degeneration of photoreceptors and secondary defect of reti- nal pigment epithelium and inner retina. Ocular blood flow of RP patients is reduced in the early stage of disease. So it is concerned to be a primary component modifying RP, which is caused by primary vascular dysfunction and elevation of endotheliml in plas- ma. Numbers of methods could be used to assess ocular blood flow effectively. Thera- peutic consequences aimed to improve vascular regulation of eyes would be helpful for RP patients. Further understanding of the relationship between ocular blood flow and RP leads to more effective treatment.

关 键 词：视网膜色素变性 血流 原发性血管功能障碍 内皮素-1 

分 类 号：R774.13[医药卫生—眼科]