HIF-1α、MMP2在大肠癌中的表达及相关性研究  

Correlation and expression of HIF-1α and MMP2 in human colorectal cancer tissue

作　　者：任亚君[1] 熊枝繁[1] 曹仕琼[1] 熊莉娜[1] 涂艳[2] 张芹[3] 熊亮[4] 程汉英[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院消化内科,湖北武汉430077 [2]华中科技大学同济医学院附属梨园医院老年病科,湖北武汉430077 [3]华中科技大学同济医学院附属梨园医院病理科,湖北武汉430077 [4]华中科技大学同济医学院附属梨园医院检验科,湖北武汉430077

出　　处：《胃肠病学和肝病学杂志》2015年第4期425-427,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：湖北省科技计划自然科学基金课题(2011CDB368)

摘　　要：目的观察缺氧诱导因子1-α(HIF-1α)、基质金属蛋白酶2(MMP2)在大肠癌发生发展过程中的表达情况及其相关性,探究其与大肠癌临床病理特征的关系。方法运用免疫组织化学(SABC)法检测HIF-1α、MMP2在46例大肠癌组织及20例正常组织中的表达情况。结果 HIF-1α、MMP2在大肠癌的阳性表达率明显高于正常大肠组织,差异有统计学意义(P<0.001)。HIF-1α、MMP2的表达均与Dukes分期及是否有淋巴结转移有关(P<0.05);通过相关性分析,两者呈正相关(r=0.357,P<0.05)。结论HIF-1α、MMP2可能与大肠癌的发生、浸润及转移有关,两者的协同作用可能参与了大肠癌的发生、发展。Objective To investigate the correlation and expression of HIF-1αand MMP2 in human colorectal canc-er tissue .Methods Immunohistochemical method （ SABC ） was used to detect the expression of HIF-1αand MMP2 protein in 46 cases of colorectal cancer and 20 cases of normal tissue .Results The positive expression rates of HIF-1αand MMP2 protein in human colorectal cancer were significantly higher than those in normal tissue （ P〈0 .001 ） .The expression of HIF-1αand MMP2 were significantly correlated with the Dukes stages and lymph node metastasis （ r=0.357,P〈0.05）.The expression of HIF-1αand MMP2 protein were significantly positive correlated （P〈0.01）. Conclusion The expression of HIF-1αand MMP2 protein may be related to the development , metastasis and invasion of human colorectal cancer , and the synergistic effects may participate in the development of the colorectal carcinoma .

关 键 词：大肠癌 缺氧诱导因子1-Α 基质金属蛋白酶2 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]