脂肪肝患者饮酒量与代谢因素相关性分析  

Correlation between alcohol consumption and metabolic factors in fatty liver disease

作　　者：袁乐媛[1] 王炳元[1] 

机构地区：[1]中国医科大学附属第一医院老年消化内分泌科,辽宁沈阳110001

出　　处：《胃肠病学和肝病学杂志》2015年第4期441-443,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：辽宁省科技攻关项目(2011225015)

摘　　要：目的探讨脂肪肝患者饮酒及饮酒量多少对代谢综合征(metabolic syndrome,MS)发生的影响。方法回顾性分析中国医科大学体检中心诊断为脂肪肝的1 868例患者,按照脂肪肝的诊断标准将其分为酒精性脂肪肝(alcoholic fatty liver disease,AFLD)和非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD),后者分为绝对不饮酒的脂肪肝(N-NAFLD)和饮酒量没有达到AFLD诊断标准的脂肪肝(D-NAFLD),分析比较其患MS的风险。结果与NAFLD相比,AFLD患者的收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、高密度脂蛋白(HDLC)、空腹血糖(GLU)显著增高(P<0.05),而体质量指数(BMI)在两组间比较,差异无统计学意义(P>0.05);与N-NAFLD相比,D-NAFLD患者SBP、HDLC、GLU显著降低(P<0.05),而BMI、TG显著升高(P<0.05),DBP在两组间比较,差异无统计学意义(P>0.05)。结论 AFLD发生MS的风险明显高于NAFLD。与N-NAFLD相比,D-NAFLD患高血压、糖尿病的风险降低,而血脂异常症及肥胖症的发病风险升高。Objective To determine the effects of alcohol consumption on the prevalence of metabolic syndrome （MS） in patients with fatty liver disease （FLD）.Methods A total of 1 868 patients diagnosed as FLD in Health Check Center of China Medical University were selected .FLD patients were divided into alcoholic fatty liver disease （ AFLD） group and nonalcoholic fatty liver disease （ NAFLD） group in accordance with the diagnostic criteria of FLD . The latter was further divided into N-NAFLD group （ those who never drank ） and D-NAFLD group （ those who drank but did not meet the diagnostic criteria for AFLD ）.Results The levels of SBP, DBP, TG, HDLC and GLU in AFLD group were higher than those in NAFLD group （ P〈0 .05 ） , while BMI showed no significant difference between two groups （P〉0.05）.The levels of SBP, HDLC, GLU in D-NAFLD group were lower than those in N-NAFLD group （P〈0.05）, while the levels of BMI and TG were higher （P〈0.05）, but there was no significant difference of DBP level between two groups （ P〉0 .05 ） .Conclusion The risk of MS in AFLD is significantly higher than that in NAFLD .The risks of hypertension and diabetes in D-NAFLD group are relatively lower , while the risks of dyslipidemia and obesity are higher compared with N-NAFLD group.

关 键 词：饮酒量 酒精性脂肪肝 非酒精性脂肪肝 代谢综合征 

分 类 号：R575[医药卫生—消化系统]