微栓子信号监测评估抗小板聚集药和他汀类药物联用治疗急性缺血性脑卒中疗效的研究  

Study on the monitoring of microembolic signal in assessing the curative effect of platelet aggregation drugs combined with statins on treating acute ischemic stroke

作　　者：谢坚[1] 王玉凯[1] 章成国[1] 张虹桥[1] 邵燕[1] 

机构地区：[1]广东省佛山市第一人民医院神经内科,528000

出　　处：《临床神经病学杂志》2015年第2期95-98,共4页Journal of Clinical Neurology

基　　金：广东省佛山市科技局立项(201308058)

摘　　要：目的应用微栓子信号(MES)监测评估抗血小板聚集药和他汀类药物联用治疗急性缺血性脑卒中的疗效。方法 62例急性缺血性脑卒中患者随机分为两组:两联治疗组(30例,采用氯比格雷加阿司匹林治疗)和瑞舒伐他汀组(32例,采用氯比格雷、阿司匹林及瑞舒伐他汀治疗)。分别在治疗前及治疗后第3d、第7 d和第14 d采用TCD监测MES。比较两组MES监测结果。结果与治疗前相比,两组治疗后第3 d、第7 d和第14 d的MES数量均明显下降(均P<0.05)。治疗后第3 d、第7 d和第14 d,瑞舒伐他汀组MES数量较两联治疗组明显下降(均P<0.05)。瑞舒伐他汀组治疗后第3 d、第7 d和第14 d的MES下降率均明显高于两联治疗组(均P<0.05)。结论两联抗血小板聚集药联用他汀类药物治疗急性缺血性脑卒中相较于单用两联抗血小板治疗可以取得更好的疗效。Objective To study the monitoring of microembolic signal （ MES） in assessing the curative effect of platelet aggregation drugs combined with statins on treating acute ischemic stroke.Methods Sixty-two patients with acute ischemic stroke were randomly divided into two groups： two couplet treatment group （30 cases, treated with Clopidogrel and Aspirin） and Rosuvastatin group （32 cases, treated with Clopidogrel, Aspirin and Rosuvastatin）. The MES was assessed by TCD before treatment and at 3 d, 7 d and 14 d after treatment, respectively.And the results of MES assessment were compared between the two groups.Results Compared with before treatment, the MES numbers of the two groups at 3 d, 7 d and 14 d after treatment were significantly decreased （all P〈0.05）.At 3 d, 7 d and 14 d after treatment, the MES numbers of Rosuvastatin group were significantly lower than those in the two couplet treatment group （ all P〈0.05） .The drop rate of MES in the Rosuvastatin group at 3 d, 7 d and 14 d after treatment were significantly higher than those in the two couplet treatment group （all P〈0.05）.Conclusion The curative effect of two couplet treatment of platelet aggregation drugs combined with statins on treating acuteischemic stroke is better than only two couplet treatment.

关 键 词：微栓子信号 缺血性脑卒中 抗血小板聚集药 他汀类药物 疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]