钠通道Nav1.7与疼痛关系的研究进展  

Relationships between sodium channel Na_V1.7 and pain

作　　者：梁晓南[1,2] 俞纲[2] 郑志兵[1,2] 苏瑞斌[1,2] 

机构地区：[1]广西医科大学药学院,广西南宁530021 [2]军事医学科学院毒物药物研究所抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《中国药理学与毒理学杂志》2015年第2期297-301,共5页Chinese Journal of Pharmacology and Toxicology

基　　金：国家"重大新药创制"科技重大专项(2012-ZX09301003-001)~~

摘　　要：电压门控型钠离子通道（NaV1.1~NaV1.9）在细胞兴奋的产生和维持过程中具有重要作用,其中NaV1.7亚型主要分布于外周初级感觉神经元和交感神经节神经元。编码NaV1.7的SCN9A基因功能增强导致先天性神经痛,而功能缺失则导致无痛症,但并不影响运动、认知和心跳。NaV1.7与一些疼痛治疗药物的作用机制相关,选择性NaV1.7阻断剂具有镇痛作用。因此,NaV1.7已成为疼痛治疗的潜在靶标。本文就NaV1.7与疼痛的关系进行综述。Voltage-gated sodium channels （NaV1.1-NaV1.9） play important roles in the generation and maintenance of electrical excitability. NaV1.7 is preferentially expressed in peripheral somatic sensory neurons and sympathetic ganglion neurons. ln humans, gain-of-function mutations of SCN9A gene, which encodes NaV1.7, cause inherited neuropathic pain, whereas loss-of-function mutations result in a congenital indifference to pain without motor, cognitive and cardiac deficits. The effects of some analge-sics are associated, at least in part, with the NaV1.7 and selective NaV1.7 inhibitors have also been demonstrated to be analgesic in animal models. NaV1.7 has emerged as a potential target for the treat-ment of pain.

关 键 词：电压门控钠离子通道 NaV1.7 疼痛 镇痛 

分 类 号：R402[医药卫生—临床医学]