肉毒毒素在肿瘤治疗和辅助治疗领域的研究进展  

Progress on botulinum toxin for tumors' therapy and adjuvant therapy

作　　者：苏娟[1] 张雪平[1] 

机构地区：[1]兰州生物制品研究所有限责任公司甘肃省疫苗工程技术研究中心,甘肃兰州730046

出　　处：《微生物学免疫学进展》2015年第2期57-61,共5页Progress In Microbiology and Immunology

摘　　要：肉毒毒素是肉毒梭状芽胞杆菌生长繁殖过程中产生的一种细菌外毒素。它可以通过抑制相关神经递质的释放而抑制神经的生理作用,目前临床适应症涉及神经内科、整形外科、康复科、泌尿科等多领域。最新研究发现,肉毒毒素作为毒蕈碱受体拮抗剂可抑制迷走神经释放乙酰胆碱,从而抑制胃癌的发生与发展。同时发现肉毒毒素可通过阻断去甲肾上腺素等神经递质的释放引起神经性的血管舒张,从而打开肿瘤神经血管网来改善肿瘤的放射和化学治疗的疗效。现就其在肿瘤治疗及其辅助治疗相关领域的研究现状进行了综述。Botulinum toxin is a bacterial exotoxin generated in the growth of the clostridium botulinum.Nervous’physiolog-ical functions can be inhibited by botulinum toxin to block release of related neurotransmitters.The toxin has a variety of clinical indications,such as neurology,orthopaedics,rehabilitation,urology.Recent study has found that the botulinum toxin as a antagonist for muscarine receptor can prevent the vagus nerve from releasing the acetylcholine,so as to surpress the occurrence and development of gastric cancer.In addition,botulinum toxin can cause neurological vasodilatation by blocking release of neurotransmitters,for example norepinephrine,leading to open the nerve tumor vascular network to im-prove the curative effect of the tumors’radiotherapy and chemotherapy.This paper reviewed the present development in re-search of botulinum toxin for tumors’therapy and adjuvant therapy.

关 键 词：肉毒毒素 M3受体 失神经作用 肿瘤 放射和化学治疗 

分 类 号：R730.5[医药卫生—肿瘤]