异常糖链糖蛋白在消化道肿瘤中的表达及其临床意义  

Expression and Clinical Significance of Tumor Abnormal Protein in Gastrointestinal Tumors

作　　者：姚淞元[1] 吴永梅[1] 

机构地区：[1]新疆医科大学第五附属医院体检中心,新疆维吾尔自治区乌鲁木齐市830011

出　　处：《职业与健康》2015年第8期1147-1149,1152,共4页Occupation and Health

基　　金：2014年新疆维吾尔自治区科技支疆项目(项目编号:201491180)

摘　　要：探讨异常糖链糖蛋白(TAP)在消化道肿瘤(GITs)中的表达及其临床意义。方法选取新疆医科大学第五附属医院门诊或住院的病例和健康检查者为研究对象,应用随机数字表法将其分为GITs患者组120例、GITs高危人群组123例和体检正常人群组117例;检测3组研究对象TAP的表达,并计算其对GITs诊断或早期诊断的灵敏性、特异性等,且随访1年半,分析TAP表达与肿瘤发生或复发的关系。结果 1 GITs患者组TAP阳性、临界表达为88.33%(106例),与GITs高危人群组24.39%(30例)以及正常人群组3.42%(4例)比较,差异有统计学意义,均P<0.01。2 TAP检测对GITs诊断或早期诊断的灵敏度为88.33%、特异度为85.83%、阳性预测值为75.71%、阴性预测值为93.64%以及约登指数为0.741 6。3随访1年半后,GITs高危人群组和体检正常人群组34例TAP阳性病例,肿瘤发生率为23.53%(8例),明显高于206例阴性病例的0.49%(1例),P<0.01。4 GITs术后33例阳性患者,1年半后肿瘤复发率33.33%(11例),明显高于87例阴性患者6.90%(6例),P<0.01。结论 TAP可以作为消化道肿瘤早期诊断、早期预防、疗效检测以及预后判定的指标。[Objective] To investigate the expression and clinical significance of tumor abnormal protein （TAP） in gastrointestinal tumors （GIT）. Method： The outpatients and inpatients as well as healthy physical examinees in the fifth Affiliated hospital of Xinjiang Medical University were chosen as objects. Using random number table, they were divided into GITs group （120 cases）, high-risk GITs group （123 cases） and normal group （117 cases）. TAP expression was detected in three groups. Its sensitivity and specificity to the diagnosis or early diagnosis of GITs were calculated. These study objects were followed up for one and a half years. Then the relationship between TAP expression and the occurrence or recurrence of tumors were analyzed. [Results]① The positive TAP with critical expression accounted for 88.33% （106 cases） in the GIT group. Compared with the ratios of 24.39% （30 cases） in the high-risk GIT group and 3.42% （4 cases） in the normal group, the difference was statistically significant（all P〈0.01）. ② TAP detection to GITs diagnosis or for early diagnosis was 88.33%, the specificity was 85.83%, was positive predictive value 75.71%, negative predictive value of 93.64% and Youden index was 0.741 6 . ③ After one and a half years＇ follow-up, for the 34 cases with positive TAP in high-risk GIT group and normal group, the tumor incidence was 23.53% （8 cases）, which was significantly higher than the incidence of 0.49% （1 case） in the rest 206 negative cases （P〈0.01）. ④ For 33 positive TAP cases receiving GIT surgery, the recurrence rate of tumor after one and a half years was 33.33% （11 cases）, which was obviously higher than the ratio of 6.90% （6 cases） in the rest 87 negative cases （P〈0.01）. [Conclusions]： TAP can be an index for early diagnosis, early prevention, detection of treatment effect and prediction of prognosis of gastrointestinal tumor.

关 键 词：异常糖链糖蛋白 检测 肿瘤 早期诊断 发生率 复发率 

分 类 号：R735[医药卫生—肿瘤]