Effects of nimodipine on changes of endothelin after head injury in rabbits  

作　　者：沈光建 邹咏文 许民辉 刘保松 徐有奇 

出　　处：《Chinese Journal of Traumatology》2001年第3期172-174,共3页中华创伤杂志（英文版）

摘　　要：Objective: To investigate the effects of nimodipine on changes of endothelin after head injury. Methods: Sixty five adult rabbits were randomized into an injury group (IG, n=30), a nimodipine treatment group (NTG, n=30) and a control group (CG, n=5). With their heads unfixed, the animals in IG and NTG were injured in the frontal parietal zone with BIM II bioimpact. Blood samples and brain tissue were collected before and after injury. The endothelin level was measured with RIA. Results: The endothelin level in plasma and brain tissue was significantly increased 24 hours after injury. At the 8th or/and 24th hours postinjury, the endothelin level was significantly lower in NTG than that in IG. Conclusions: Nimodipine can prevent endothelin from elevation and act as a practical endothelin antagonist after head injury clinically.

关 键 词：Head injuries ENDOTHELINS RABBITS NIMODIPINE 

分 类 号：R651.15[医药卫生—外科学] R972[医药卫生—临床医学]