干眼症眼表损害炎症机制  

Inflammatory mechanisms in ocular surface damage of dry eye

作　　者：宿梦苍 郝晓琳[1] 张仲臣[1] 

机构地区：[1]航天中心医院眼科,中国北京市100049 [2]辽宁医学院研究生学院,中国辽宁省锦州市121001

出　　处：《国际眼科杂志》2015年第5期821-824,共4页International Eye Science

摘　　要：干眼症为一种多因素造成泪膜稳定性和眼表功能损害的疾病,易引起眼部不适、视力障碍、泪膜不稳定与眼表的潜在危害,可伴有泪液渗透压升高及眼表炎症反应。炎症是干眼发病中最关键因素,多种免疫细胞和炎症因子参与了干眼症的发生与发展过程。细胞凋亡、神经调节异常、性激素失调等也共同参与了干眼的发病过程。最近尽管在阐述干眼的病理生理和发病机制取得了一定进展,但目前还未形成统一标准。本文将对炎症造成干眼症眼表和泪液功能损害的可能机制进行综述。Dry eye is a multi-factorial disease of tear film and ocular surface, and it can result in discomfort, visual disturbance and tear film instability and potential damage of ocular surface, accompanied by hyper osmolarity of tears and ocular surface inflammation. lnflammation is the key factor to dry eye. Many kinds of immune cells and inflammatory factors are involved in the occurrence and deveIOPment of dry eye syndrome. Cell apoptosis, nerve dysregulation, disorders of sex hormones also play an important role in pathologic process of dry eye. Recently, while illustrating the pathophysiology and pathogenesis of dry eye has been made some progress, there is still no single standard. The possible mechanisms of ocular surface inflammation and tear dysfunction of dry eye were reviewed in this article.

关 键 词：干眼症 炎症 T 淋巴细胞 细胞因子 泪液渗透压 

分 类 号：R777.34[医药卫生—眼科]