透明细胞乳头状肾细胞癌临床病理观察  

Clear cell papillary renal cell carcinoma:a clinicopathological analysis

作　　者：王功伟[1] 王颖[1] 陈云新[1] 沈丹华[1] 

机构地区：[1]北京大学人民医院病理科,北京100044

出　　处：《诊断病理学杂志》2015年第4期208-211,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨透明细胞乳头状肾细胞癌(CCPRCC)病理学特征以及鉴别诊断。方法研究1例透明细胞乳头状肾细胞癌,观察组织病理学表现、行免疫组化染色以及遗传学检测,同时复习相关文献。结果肿瘤直径2 cm,切面实性、灰红色。镜下典型表现是肿瘤细胞囊腔内形成乳头状生长方式;瘤细胞胞质透明并且较温和,轻度异型性,细胞核Fuhrman分级为1级;间质中可见少量平滑肌细胞以及"流产型"血管。免疫组化:肿瘤PAX2、PAX8、CK7、CA-IX、HMWCKs、EMA和vimentin(+),间质成分desmin、caldesmon、SMA和actin(+)。FISH检测未发现17号染色体获得。随访8个月肿瘤无复发。结论 CCPRCC是一种少见的肾肿瘤,病理学诊断较为复杂,需要与多种病变进行鉴别。Objective To investigate the pathological features and differential diagnosis of clear cell papillary renal cell carcinoma （CCPRCC）. Methods We studied one case of CCPRCC and observed its histopathologic, immunohistochemical staining and genetic test, and reviewed the relevant literature. Results The diameter of tumor was 2. 0 cm. Its cut surface was red to gray. The typical manifestation was papillary formation in a cystic growth pattern. The transparent cytoplasm was its most prominent feature of tumor cells. These cell nuclei were mild atypia, and Fuhrman grade 1. There was a small amount of smooth muscle tissue and abortive vessel at interstitial component. The neoplastic component showed immunoreactivity for PAX2, PAXS, CK7, CA-IX, and HMWCKs. We did not find the deletion of chromosome 17 in FISH test. We did also not find tumor recurrence by the following-up for eight months. Conclusions CCPRCC is a rare tumor of the kidney. The diagnosis of CCPRCC is complex at pathology. It is necessary to distinguish from a variety of diseases.

关 键 词：透明细胞乳头状肾细胞癌 病理学 鉴别诊断 

分 类 号：R737.11[医药卫生—肿瘤]