突变型p53和Pgp在结直肠癌中表达的意义  

Expression of p53 and P-glycoprotein in colorectal carcinomas and their significance

作　　者：裴笑月[1] 胡波[1] 孙静阳[1] 孙海姣[1] 李晓慧[1] 童细焱[1] 

机构地区：[1]大连大学附属新华医院病理科,辽宁大连116021

出　　处：《诊断病理学杂志》2015年第4期233-236,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨突变型p53和Pgp蛋白在结直肠癌中表达的临床病理意义。方法采用免疫组化SP法检测751例结直肠癌组织中突变型p53和Pgp蛋白的表达,SPSS13.0统计分析两种蛋白表达的临床病理学意义及其相关性。结果突变型p53和Pgp蛋白在结直肠癌组织中的阳性率分别为50.7%(381/751)和72.2%(542/751);p53蛋白在直肠癌组织及中分化癌组织中的阳性率均明显高于其在结肠癌组织和高、低分化癌组织中的阳性率(P<0.05),Pgp蛋白的阳性率与所有临床病理参数均无明显相关性(P>0.05);在结直肠癌组织中,突变型p53和Pgp蛋白的表达呈正相关性(P<0.05)。结论结直肠癌组织中存在突变型p53和Pgp蛋白的异常表达,联合检测这两种蛋白或许对结直肠癌多药耐药的分子机制提供一定的临床依据。Objective To investigate the expression and significance of p53 and P-glycoprotein （Pgp） in colorectal carcinomas. Methods The protein expression of p53 and Pgp in 751 cases of colorectal carcinomas was detected by immunohistochemical method and the correlation of clinicopathological factors with their expression was analyzed by SPSS13.0. Results The positive rates of P53 and Pgp expression in coloreetal carcinomas were 50. 7% （381/751） and 72. 2% （542/751）, respectively. The expression rates of p53 in the groups of rectal and moderately differentiated carcinomas were significantly higher than those of the groups of colon and well or poorly differentiated ones （P 〈 0.05 ,P = 0. 016, 0. 002）. The expression of Pgp had no relationship with all clinicopathological factors （P 〉 0. 05 ）. A significant relationship was also observed between the expression of p53 and that of Pgp in colorectal carcinomas （ r = 0. 12, P = 0. 004）. Conclusions There is abnormal expression of p53 and Pgp proteins in colorectal carcinomas, and combined detection of these two proteins may be help in determining the muhidrug resistance of colorectal carcinoma cells.

关 键 词：结直肠癌 突变型P53 P53 

分 类 号：R735.35[医药卫生—肿瘤]