重复经颅磁刺激对脑梗死后轻度认知功能损害患者的研究  

Effects of repetitive transcranial magnetic stimulation on cognitive function in post-cerebral infarction patients with mild cognitive impairmen

作　　者：唐向阳[1] 袁良津[1] 蒋鸣坤[1] 陈祚胜[1] 

机构地区：[1]安徽医科大学附属安庆医院神经内科,安庆246003

出　　处：《卒中与神经疾病》2015年第2期76-79,共4页Stroke and Nervous Diseases

摘　　要：目的探讨重复经颅磁刺激(repetitive trancranial magnetic stimulation,r TMS)对脑梗死后轻度认知功能障碍(mild congnitive impairment,MCI)患者的影响。方法采用单盲-随机分组方法,将60例脑梗死后轻度认知功能障碍的患者按首诊先后顺序随机分成r TMS治疗组和对照组,每组各30例,2组受试者均予常规药物作为背景治疗。r TMS治疗组患者同时给予r TMS治疗。分别于治疗前、后进行事件相关电位P300检查和蒙特利尔认知评估量表(Mo CA)评分。结果 r TMS治疗组患者治疗后与治疗前比较,P300潜伏期明显缩短(t=8.84,P<0.05)、波幅明显增高(t=-6.64,P<0.05),Mo CA量表总分(t=-7.87,P<0.05)和记忆测试得分(t=-6.26,P<0.05)明显增高;且与对照组比较,差异亦均明显(P<0.05)。而对照组患者治疗后与治疗前P300潜伏期、波幅及Mo CA量表总分和各分项得分之间的差异均不明显(P>0.05)。结论 r TMS能改善脑梗死患者的轻度认知功能障碍,且安全性好。Objective To explore the effects of repetitive transcranial magnetic stimulation （rTMS） on cognitive function and safety in post-cerebral infarction patients with mild cogrfitive impairmen（MCI）. Methods Patients with MCI were randomly divided into two groups： the rTMS treatment group（n = 30） and control group （n = 30）. Event-related potentis1 （ERP） P300 latency and amplitude, MoCA scores were recorded for two groups before and after 4 weeks rTMS treatment. P300 latency and amplitude and MoCA scores were as- sessed and compared. Results Compared with the control group, patients treated with rTMS had significant improvement in P300 latency（t = -6. 64,P〈~0. 05）and amplitude（t = - 7. 87,P^0. 05）, as well as in scores of MoCA, especially of the memory test （t = -6. 26,P^0. 05）. in control group, no difference existed in P300 and MoCA scores （P^0. 05）. Conclusions rTMS can improve cognitive function in post-cerebral infarction patients with mild cognitive impairmen, it was a safe therapeutic method in post-cerebral infarction patients with MCI.

关 键 词：重复经颅磁刺激 脑梗死 轻度认知功能障碍 

分 类 号：R749.13[医药卫生—神经病学与精神病学]