Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ  

蝙蝠葛碱对在体家兔左心室单相动作电位和有效不应期的影响(英文)

作　　者：夏敬生[1] 李真[2] 董建文 屠洪 曾繁典[2] 

机构地区：[1]中国科学院上海生理研究所低氧心血管生理实验室,上海200031 [2]同济医科大学临床药理研究所,武汉430030 [3]广东深圳红十字会医院心内科

出　　处：《Acta Pharmacologica Sinica》2002年第4期371-375,共5页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China, № 39670834.

摘　　要：AIM: To study the effects of dauricine and sotalol on monophasic action potentials and effective refractory period of the rabbit heart in situ. METHODS: Monophasic action potentials recording and programmed electrical stimulation techniques. RESULTS: Iv injection of dauricine 0.5 mg · kg-1 · min-1 for 24 min produced a decrease of the amplitude of monophasic action potentials from (17±6) mV to (7.1±1.5) mV (P < 0.05) and increased the duration of 50 % and 90 % repolarization of monophasic action potentials and effective refractory period from (130±26), (167 ± 25), (128±12) ms to (198±33), (235±34), (185 ±25) ms ( P < 0.05), respectively. Sotalol had the similar effects on monophasic action potentials and effective refractory period to that of dauricine. Dauricine and sotalol did not change the ratio between effective refractory period and the duration of 90 % repolarization. CONCLUSION: Dauricine and sotalol decreased the amplitude of monophasic action potentials and increased the duration of 50 % and 90 % repolarization and effective refractory period.目的:研究蝙蝠葛碱(Dau)和索他洛尔对在体家兔左心室单相动作电位和有效不应期的作用.方法:采用单相动作电位测定技术记录家兔在体心脏单相动作电位,用程序电刺激法测定左心室有效不应期.结果:Dau 0.5mg·kg^(-1)·min^(-1)恒速静脉灌注明显降低单相动作电位幅度,由用药前的(17±6)mV降至给药后24min的(7.1±1.5)mV.Dan显著延长单相动作电位复极50％和90％时程及有效不应期,给药前分别为(130±26),(167±25),(128±12)ms,给药后24min分别延长至(198±33),(235±34),(185±25)ms.但对有效不应期与单相动作电位时程(MAPD_(90))之比值无明显影响.索他洛尔对上述各指标的作用与Dau相似.结论:研究结果表明,Dau和索他洛尔降低单相动作电位幅度,延长单相动作电位时程和有效不应期.

关 键 词：DAURICINE SOTALOL RABBITS action potentials 

分 类 号：R96[医药卫生—药理学]