DAURICINE

作品数:12被引量:66H指数:5
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相关领域:医药卫生更多>>
相关作者:曾繁典郭东林胡崇家周兆年夏敬生更多>>
相关机构:华中科技大学同济医科大学中国科学院上海生命科学研究院中国科学院上海生理研究所更多>>
相关期刊:《Journal of Pharmaceutical Analysis》《Asian Pacific Journal of Tropical Medicine》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金:国家自然科学基金更多>>
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Dauricine can inhibit the activity of proliferation of urinary tract tumor cells被引量:8
《Asian Pacific Journal of Tropical Medicine》2012年第12期973-976,共4页Jun Wang Yuan Li Xiong-Bing Zu Min-Feng Chen Lin Qi 
Objective:To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain,prostate cancer PC-3Mcell strain and primary cell culture system.Methods:The main effective...
关键词:PAMD DAURICINE URINARY system EJ CELL STRAIN PC-3Mcell STRAIN 
Dauricine inhibits insulin-like growth factor-Ⅰ-induced hypoxia inducible factor la protein accumulation and vascular endothelial growth factor expression in human breast cancer cells被引量:11
《Acta Pharmacologica Sinica》2009年第5期605-616,共12页Xu-dong TANG Xin ZHOU Ke-yuan ZHOU 
Acknowledgements This work was supported by the grants from the National Natural Science Foundation of China (No 30872944), the Guangdong Administration of Traditional Chinese Medicine (No 2008166), and the Department of Science and Technology of Dongguan (No 2008108101029). We thank Prof Xiong-tai GUAN (Guangdong Medical College, Zhanjiang, China) for kindly providing Dau. We also thank Dr Anh D Le and Dr Qun-zhou ZHANG (Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, USA) for their technical assistance and strong support.
Aim: To investigate the effects of dauricine (Dau) on insulin-like growth factor-Ⅰ (IGF-Ⅰ)-induced hypoxia inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression in human br...
关键词:DAURICINE ANGIOGENESIS insulin-like growth factor-Ⅰ hypoxia inducible factor  vascular endothelial growth factor 
Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs被引量:2
《Acta Pharmacologica Sinica》2003年第10期1011-1015,1062,共6页师少军 陈汇 顾世芬 曾繁典 
Project supported by the Scientific Research Foundation of Committee of Science and Technology of Hubei Province. №991P1609.
AIM: To study the combined pharmacokinetic-pharmacodynamic(PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs. METHODS: Th...
关键词:DAURISOLINE DAURICINE PHARMACOKINETICS PHARMACODYNAMICS 
Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives被引量:23
《Acta Pharmacologica Sinica》2002年第12期1086-1092,共7页钱家庆 
Project supported by Scientific Foundation of Ministry of Health of China,№ 96-1-134.
Tetrandrine, dauricine, daurisoline and neferine are bisbenzylisoquinoline alkaloid derivatives isolated from Chinese traditional medicine and herbs. The cardiovascular pharmacological effects and the mechanism of act...
关键词:Chinese traditional medicine TETRANDRINE DAURICINE DAURISOLINE NEFERINE cardiovascular system calcium channel blockers antihypertensive agents anti-arrhythmia agents 
Dauricine-induced changes in monophasic action potentials and effective refractory period of rabbit left ventricle in situ被引量:1
《Acta Pharmacologica Sinica》2002年第4期371-375,共5页夏敬生 李真 董建文 屠洪 曾繁典 
Project supported by the National Natural Science Foundation of China, № 39670834.
AIM: To study the effects of dauricine and sotalol on monophasic action potentials and effective refractory period of the rabbit heart in situ. METHODS: Monophasic action potentials recording and programmed electrical...
关键词:DAURICINE SOTALOL RABBITS action potentials 
Metabolism of Dauricine and Identification of Its Main Metabolites
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2000年第3期253-256,共4页陈淑娟 刘力 杨毅梅 戴宗顺 曾繁典 
This project was suported by a grant from the foundation of Youth Sciences and Technology Chenguang Planning ofWuhan (No.2 0
To study the metabolism of dauricine in vivo and in vitro and identify the structure of its main metabolites, urine of rats after drug administration as the samples of dauricine metabolism in vivo was studied. Rat liv...
关键词:DAURICINE METABOLISM METABOLITE HPLC  DAD ESI/MS 
A Sensitive HPLC Technique for the Quantitation of Dauricine被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2000年第1期39-42,共4页陈淑娟 杨毅梅 张力 庞雪冰 代宗顺 曾繁典 
Summary: To establish the determination method of dauricine (Dan) concentration in rats' blood and other biological samples, a reverse-phase HPLC method was adopted. Under the given condition, dauricine could be well...
关键词:DAURICINE RP-HPLC concentration determination 
Inhibitory effects of dauricine on potassium currents in guinea pig ventricular myocytes^1被引量:2
《Acta Pharmacologica Sinica》2000年第1期62-66,共5页夏敬生 郭东林 张翼 周兆年 曾繁典 胡崇家 
Project supported by the National Natural Science Foundation of China. No 39670834.
AIM: To study the effects of dauricine(Dau) on the rapidly activating component (Ikr), the slowly activating component (Iks) of the delayed rectifier potassium current, and the inward rectifier potassium current (Ikl)...
关键词:DAURICINE MYOCARDIUM potassium channels patch-clamp techniques 
EFFECT OF DAURICINE ON PLATELET ACCUMULATION IN THE PULMONARY CIRCULATION OF RABBITS
《Journal of Pharmaceutical Analysis》1999年第2期120-124,共5页Liu Juntian Department of Pharmacology, Xi′an Medical University, Xi′an 710061 
Intravenous injection of platelet agonists ADP and thrombin induced the accumulation of 111 In labelled platelets within the pulmonary vasculature. Pretreatment with i.v. administration of Dauricine significan...
关键词:DAURICINE PLATELET ADP THROMBIN 
Effect of Dauricine on Redistribution of Glycoprotein Ⅳ in Platelet Membrane of Patients with Mitral Stenosis
《Chinese Journal of Integrative Medicine》1998年第4期250-250,共1页张彦周 刘东旭 李裕舒 冯义柏 毛焕元 
Objective: To investigate the effect of dauricine on the irreversible platelet aggregability of patients with mitral stenosis (MS).Methods: Glycoprotein Ⅳ (GPⅣ ) and thrombospondin (TSP) levels on the membrane surfa...
关键词:Effect of Dauricine on Redistribution of Glycoprotein in Platelet Membrane of Patients with Mitral Stenosis 
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