DAURISOLINE

作品数：6被引量：29H指数：2
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相关领域：医药卫生更多>>
相关作者：钱家庆李瑞刘国卿刘景根师少军更多>>
相关机构：华中科技大学中国药科大学空军军医大学（第四军医大学）南昌大学更多>>
相关期刊：《Chinese Journal of Chemistry》《Medicinal Plant》《Acta Pharmacologica Sinica》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金更多>>
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Advances in Research of Pharmacological Effects and Molecular Mechanisms of Daurisoline
《Medicinal Plant》2022年第3期87-91,共5页Quan QUAN Chenghao JIN 
Supported by Central Government Supporting Local College Reform and Development Fund Talent Training Project (2020GSP16)
Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,a...
关键词：DAURISOLINE Pharmacological effects Calcium regulation ANTICANCER 
Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs被引量：2
《Acta Pharmacologica Sinica》2003年第10期1011-1015,1062,共6页师少军 陈汇 顾世芬 曾繁典 
Project supported by the Scientific Research Foundation of Committee of Science and Technology of Hubei Province. №991P1609.
AIM: To study the combined pharmacokinetic-pharmacodynamic(PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs. METHODS: Th...
关键词：DAURISOLINE DAURICINE PHARMACOKINETICS PHARMACODYNAMICS 
Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives被引量：23
《Acta Pharmacologica Sinica》2002年第12期1086-1092,共7页钱家庆 
Project supported by Scientific Foundation of Ministry of Health of China,№ 96-1-134.
Tetrandrine, dauricine, daurisoline and neferine are bisbenzylisoquinoline alkaloid derivatives isolated from Chinese traditional medicine and herbs. The cardiovascular pharmacological effects and the mechanism of act...
关键词：Chinese traditional medicine TETRANDRINE DAURICINE DAURISOLINE NEFERINE cardiovascular system calcium channel blockers antihypertensive agents anti-arrhythmia agents 
l-S·R-daurisoline protects cultured hippocampal neurons against glutamate neurotoxicity by reducing nitric oxide production被引量：5
《中国药理学报》1999年第1期21-26,共6页刘景根 李瑞 刘国卿 
目的：探讨ｌＳ·Ｒ蝙蝠葛苏林碱（ＤＳ）保护神经元的作用机制．方法：原代培养大鼠海马神经细胞，用台盼蓝染色和ＭＴＴ法检测神经细胞损伤，以去内皮的大鼠胸主动脉作为分析ＮＯ含量的生物检测器．结果：ＤＳ００１－１０μｍ...
关键词：蝙蝠葛苏林碱 一氧化氮 神经细胞损伤 谷氨酸 
EFFECTS OF DAURISOLINE ON CYTOSOLIC FREE CALCIUMIN FETAL RAT CEREBRAL CELLS
《Chinese Medical Journal》1995年第4期27-30,共4页车建途 张均田 屈志炜 彭新琦 
Cytosolic free Ca([Ca]i)was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in[Ca]i occurred rapidly following explsure of the cells to 50 mmol/L KCI,1...
关键词：Ca In EFFECTS OF DAURISOLINE ON CYTOSOLIC FREE CALCIUMIN FETAL RAT CEREBRAL CELLS IO LD 
Circular dichroism of tail-to-tail bisbenzylisoquinoline and the absolute configuration of daurisoline isolated from Menispermum dauricum
《Chinese Journal of Chemistry》1991年第3期275-278,共0页KONG,Rong-Zu KUANG,Dai-Wu HUA,Wei-Yi Department of Pharmaceutical Chemistry,China Pharmaceutical University,Nanjing 210009MIN,Zhi-Da ZHAO,Shou-Xun Department of Phytochemistry,China Pharmaceutical University,Nanjing 210009MIZUNO,Mizuo IINUMA,Munekazu TANAKA,Toshiyuki Department of Pharmacognosy,Gifu Pharmaceutical University,5-6-1 Mitahora-higashi,Gifu 502,Japan 
This work was supported by the National Natural Science Foundation of China.
Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectr...
关键词：RR RS CD Circular dichroism of tail-to-tail bisbenzylisoquinoline and the absolute configuration of daurisoline isolated from Menispermum dauricum 
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