NEFERINE

作品数：19被引量：87H指数：6
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相关领域：医药卫生更多>>
相关作者：钱家庆徐智李青曹宏宇郭治彬更多>>
相关机构：中南大学华中科技大学江西医学院第一附属医院南华大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Journal of Chinese Pharmaceutical Sciences》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis被引量：3
《Journal of Traditional Chinese Medicine》2024年第1期44-53,共10页HUANG Hongmei YANG Maojun LI Ting WANG Dandan LI Ying TANG Xiaochi YUAN Lu GU Shi XU Yong 
the Chengdu Health and Wellness Commission:Exploring the Mechanism of Neferine on Diabetic Nephropathy Based on mi R-17/Nrf2 Axis(No.2021127)。
OBJECTIVE:To investigate the effect of Neferine(Nef)on diabetic nephropathy(DN)and to explore the mechanism of Nef in DN based on miRNA regulation theory.METHODS:A DN mouse model was constructed and treated with Nef.S...
关键词：diabetic nephropathies NEFERINE miR-17-5p NF-E2-related factor 2 oxidative stress 
Reversal of doxorubicin resistance in lung cancer cells by neferine is explained by nuclear factor erythroid-derived 2-like 2 mediated lung resistance protein down regulation被引量：1
《Cancer Drug Resistance》2020年第3期647-665,共19页Poornima Paramasivan Jothi Dinesh Kumar Rathinasamy Baskaran Ching Feng Weng Viswanadha Vijaya Padma 
Aim:Development of multi drug resistance and dose limiting cardiotoxicity are hindering the use of Doxorubicin(Dox)in clinical settings.Augmented dox efflux induced by lung resistance protein(LRP)over expression has b...
关键词：DOXORUBICIN NEFERINE reactive oxygen species lung resistance protein nuclear factor erythroid-derived 2-like 2 multidrug resistance 
Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells被引量：4
《Acta Biochimica et Biophysica Sinica》2019年第7期734-742,共9页Eun-Ae Kim Eon-Gi Sung In-Hwan Song Joo-Young Kim Hwa-Jung Sung Ho-Yong Sohn Jong-Yi Park Tae-Jin Lee 
Neferine is an alkaloid extracted from a seed embryo of Nelumbo nucifera and has recently been shown to have anticancer effects in various human cancer cell lines. However, the detailed molecular mechanism of neferine...
关键词：NEFERINE Caki-1 BCL-2 NF-κB P65 
Development of a cell-based HTS adaptable calcium fluorescent assay in FlexStation3 for the screening of TRPV3 inhibitors
《Journal of Chinese Pharmaceutical Sciences》2017年第9期675-683,共9页Xiaomei Sun Ningning Wei Xiaoying Sun Kewei Wang 
The National Natural Sciences Foundation of China(Grant No.81573410);the Ministry of Science and Technology of China(Grant No.2014ZX09507003-006-004);the Natural Sciences Foundation of Shandong Province(Grant No.ZR2015QL008)
To develop a cell-based high-throughput calcium fluorescent assay for screening of TRPV3 channel modulators, we employed the FlexStation3 microplate reader and optimized conditions of the high-throughput screening （...
关键词：TRPV3 inhibitor NEFERINE FlexStation3 Whole-cell patch clamp CALCIUM 
A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis被引量：6
《Chinese Chemical Letters》2016年第12期1755-1758,共4页Xiao-Xiao Zhang Shuang-ChengMa Peng Mao Ya-Dan Wang 
financially supported by 12th Five-Year Plan Major New Drug Discovery Science and Technology Projects for support of this research (No.2014ZX09304307-002)
One new bisbenzylisoquinoline alkaloid, neferine N-oxide （1）, along with three known compounds, neferine （2）, liensinine （3）, and isoliensinine （4）, were isolated from Plumulanelumbinis - the embryo of the see...
关键词：Plumulanelumbinis Bisbenzylisoquinoline alkaloid Neferine N-oxide ORAC assay Antioxidative activity 
Inhibitory Effects of Neferine on Na_v1.5 Channels Expressed in HEK293 Cells被引量：2
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第4期487-493,共7页王琛 王换 肖军花 王嘉陵 向继洲 汤强 
Neferine, a bisbenzylisoquinoline alkaloid in Lotus Plumule, was proved to have a wide range of biological activities. In the present study, using whole-cell patch-clamp technique, we investigated the effects of nefer...
关键词：NEFERINE Nay1.5 channel whole-cell patch-clamp HEK293 cells 
Effects of neferine on Kv4.3 channels expressed in HEK293 cells and ex vivo electrophysiology of rabbit hearts被引量：4
《Acta Pharmacologica Sinica》2015年第12期1451-1461,共11页Chen WANG Yu-fang CHEN Xiao-qing QUAN Huan WANG RuiZHANG Jun-hua XIAO Jia-ling WANG Cun-tai ZHANG Ji-zhou XIANG Qiang TANG 
Aim： Neferine is an isoquinoline alkaloid isolated from seed embryos of Nelumbo nucifera （Gaertn）, which has a variety of biological activities. In this study we examined the effects of neferine on Kv4.3 channels, ...
关键词：NEFERINE Kv4.3 HEK293 cells whole-cell patch-clamp rabbit left ventricular wedge action potential duration ELECTROCARDIOGRAPHY 
Effects of co-administraton of neferine and doxorubicin on the pharmacokinetics of doxorubicin被引量：2
《Journal of Chinese Pharmaceutical Sciences》2015年第4期225-230,共6页薛清丹 鞠爱霞 康宇红 郑春雨 李秋红 
The Scientific Research Fund Project of Heilongjiang University of Chinese Medicine(Grant No.201420)
Doxorubicin is one of the anthracycline anti-neoplastic drugs widely used to treat leukemia, liver, breast, and ovarian cancers and other solid tumors. However, its clinical applications have been limited by its serio...
关键词：Neferine Doxorubicin Pharmacokinetics HPLC method Anthracycline anti-neoplastic drugs 
Synergistic Effect of Hyperthermia and Neferine on Reverse Multidrug Resistance in Adriamycin-resistant SGC7901/ADM Gastric Cancer Cells被引量：10
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第4期488-496,共9页黄程辉 李亚萍 曹培国 谢兆霞 秦志强 
supported by grants from Natural Science Foundation of Hunan Province(No.07JJ4009);Project of the Department of Science and Technology of Hunan Province(No. 2010FJ6029);Research and Innovation Conditions Project of Hunan Province(No.2010TT2034);125 Talent Project of the Third Xiangya Hospital of Central South University;the Freedom Explore Program of Central South University(No. 2011QNZT193),China
Multidrug resistance（MDR） plays a major obstacle to successful gastric cancer chemotherapy.The purpose of this study was to investigate the MDR reversal effect and mechanisms of hyperthermia in combination with nefe...
关键词：gastric cancer multidrug resistance HYPERTHERMIA NEFERINE MDR-1 P-glycoprotein ADRIAMYCIN 
Neferine inhibits angiotensin Ⅱ-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1被引量：6
《Acta Pharmacologica Sinica》2010年第6期679-686,共8页Xiao-chun LI Guo-xin TONG Yu ZHANG Shan-xin LIU Qi-hui JIN Huai-hong CHEN Peng CHEN 
Aim： To explore the effect of neferine on angiotensin Ⅱ （Ang Ⅱ）-induced vascular smooth muscle cell （VSMC） proliferation. Methods： Human umbilical vein smooth muscle cells （HUVSMCs） were used. Cell prolifera...
关键词：NEFERINE heme oxygenase-1 angiotensin Ⅱ zinc protoporphyrin vascular smooth muscle cells cell proliferation 
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