丹参川芎嗪注射液治疗脑血栓的疗效分析  

Analysis on the Curative Effect of Salvia Miltiorrhiza Ligustrazine Injection on Cerebral Thrombosis

作　　者：吴成思[1] 杜明艳[1] 谈晓牧[1] 

机构地区：[1]北京市通州区潞河医院神经内科,北京101149

出　　处：《医学综述》2015年第9期1706-1707,共2页Medical Recapitulate

摘　　要：目的探讨丹参川芎嗪注射液治疗脑血栓患者的临床效果。方法选择2010年1月至2011年12月在北京市通州区潞河医院住院的156例脑血栓患者,采用随机数字表法将患者分为对照组(79例)和研究组(77例)。对照组采用常规方法治疗,研究组在对照组基础上采用丹参川芎嗪注射液治疗。观察两组的疗效以及治疗前后血液流变学的变化。结果对照组总有效率为75.9%,研究组的总有效率为87.0%,两组疗效比较差异有统计学意义(P<0.05)。治疗后,研究组血液流变学指标(全血比黏度低切、全血比黏度高切、血浆比黏度、血小板聚集率)均显著降低于对照组[(4.15±0.21)m Pa·s比(5.45±0.46)m Pa·s,(4.02±0.24)m Pa·s比(5.23±0.43)m Pa·s,(1.35±0.12)比(1.93±0.16),(46.66±12.94)%比(55.67±12.95)%,P<0.05],且均较治疗前显著降低。两组患者均未出现明显的不良反应。结论丹参川芎嗪注射液治疗脑血栓具有显著的临床疗效,可明显改善血液黏稠度。Objective To investigate the clinical effect of salvia miltiorrhiza ligustrazine injection in the treatment for cerebral thrombosis. Methods A total of 156 patients with cerebral thrombosis hospitalized in Luhe Hospital of Tongzhou District from Jan. 2010 to Dec. 2011 were selected and divided into the research group（77 cases） and the control group（79 cases） by random number table method. Patients in the control group were treated with the conventional method, while patients in the research group were treated with salvia miltiorrhiza lignstrazine injection on the basis of the treatment in control group. The total effective rates of the two group 5 after treatment were observed and the changes of blood rheology were compared between the two groups before and after treatment. Results The total effective rate of the control group was 75.9%, while the total effective rate of the research group was 87.0%, the difference was statistically significant （ P 〈 0. 05 ）. After treatment, compared with the control group, the blood rheology indexes （ whole blood low shear viscosity,whole blood high shear viscosity, ratio of viscosity, platelet aggregation rate） of the research group were significantly lower[ （4. 15 ±0. 21 ） mPa · s vs （5.45 ± 0. 46） mPa · s, （4. 02 ± 0. 24） mPa · s vs （5.23 ±0.43） mPa · s,（1.35 ＋O. 12） vs （1.93 ＋0. 16） ,（46.66 ±12.94）% vs （55.67 ±12.95）%, P 〈 0.05 ] ,besides,the blood rheology indexes of two groups were significantly decreased after treatment. There were no obvious adverse reactions occurred in both groups. Conclusion Salvia miltiorrhiza ligus- trazine injection has significant clinical curative effect on cerebral thrombosis, and it can significantly improve the blood viscosity. Key words：Cerebral thrombosis; Salvia miltiorrhiza ligustrazine; Curative effect

关 键 词：脑血栓 丹参川芎嗪 疗效 

分 类 号：R741[医药卫生—神经病学与精神病学]