Notch通路在骨肉瘤发病机制中的研究现状  

The research status of the role of notch signaling in the pathogenesis for osteosarcoma

作　　者：侯晓[1] 李纯璞[1] 陈元振[1] 倪梅[1] 郭冬梅[1] 张开刚[1] 

机构地区：[1]山东省泰安市中心医院,271000

出　　处：《中国矫形外科杂志》2015年第9期804-807,共4页Orthopedic Journal of China

基　　金：山东省自然科学基金(项目编号:ZR2012HL38);山东省优秀中青年科学家科研奖励基金(项目编号:BS2013SF030)

摘　　要：骨肉瘤是最常见的骨恶性肿瘤之一,很多报道均已证明Notch信号通路与肿瘤细胞的增殖、分化及转移等有着内在的联系。最新研究表明Notch通路与骨肉瘤的增殖、分化及耐药性等也有一定的相关性。了解Notch通路与骨肉瘤及其血管形成的关系可为临床预防及诊治骨肉瘤提供可靠的理论依据,有利于拓展预防和治疗骨肉瘤的新途径。Osteosarcoma is the most common type of bone cancer,numerous studies have proven that Notch signaling pathway and tumor cell proliferation,differentiation and metastasis are closely linked. Recent studies have found that Notch pathway also has some relevance with proliferation,differentiation and drug resistance of osteosarcoma cell. Understanding relationship of Notch signaling pathway and angiogenesis of osteosarcoma can provide new theoretical basis for clinical treatment for osteosarcoma,and can explore a new approach to prevention and treatment of osteosarcoma.

关 键 词：NOTCH信号通路 骨肉瘤 分子机制 

分 类 号：R738.1[医药卫生—肿瘤]