CXCL16及其受体CXCR6在中重度牙周炎患者牙龈组织中的表达  

Expression of CXC chemokine ligand 16 and chemokine receptor 6 in periodontal tissues of patients with moderately severe periodontitis

作　　者：孙晓菊[1] 侯俊池 谢洪[1] 张辉[1] 邓巍[1] 王云[1] 

机构地区：[1]辽宁省人民医院口腔科,辽宁沈阳110016

出　　处：《上海口腔医学》2015年第2期193-198,共6页Shanghai Journal of Stomatology

基　　金：辽宁省科学技术计划项目(2013225021)~~

摘　　要：目的：观察趋化因子CXCL16及其受体CXCR6在中重度牙周炎牙龈组织和健康牙龈组织中的表达及相互关系。方法：收集辽宁省人民医院口腔科门诊就诊和住院患者的牙龈组织79例,其中健康牙龈组40例,中、重度牙周炎组39例,年龄35-74岁。采用免疫组织化学染色法观察牙龈组织中CXCL16和CXCR6的阳性细胞百分率和染色强度。采用SPSS15.0软件包对数据进行统计学分析。结果：与健康牙龈组相比,CXCL16在中重度牙周炎组中的表达显著升高（P〈0.05）,CXCR6在中重度牙周炎组中的表达较健康牙龈组显著升高（P〈0.05）。经相关性分析,CXCLl6与CXCR6在中重度牙周炎患者牙龈组织中的表达呈正相关（r=0.580,P〈0.05）;而在健康牙龈组织中,两者的表达无相关性。结论：趋化因子CXCLl6及其受体CXCR6可能与牙周炎的发病有关,两者在牙周炎的发病过程中可能共同发挥作用。PURPOSE： To investigate the expression and localization of CXCL16 and its receptor CXCR6 in gingival tissues of patients with chronic periodontitis and analyze the roles in the occurrence and development of periodontitis. METHODS： Gingival tissues with moderately severe periodontitis were collected from 39 patients treated in People＇s Hospital of Liaoning Province. Forty persons with healthy gingiva were used as control. The age of the enrolled subjects ranged from 35 to 74 years old. Immunohistochemical technique was applied to detect the expression and localization of CXCL16 and CXCR6 protein gingival tissues of all subjects. The data was analyzed with SPSS 15.0 software package. RESULTS： Compared with normal group, the expression of CXCLI6 and CXCR6 were significantly up-regulated in patients with periodontitis （P〈0.05）. There was a positive relationship between the protein expression of CXCL16 and CXCR6 in gingival tissues of patients with periodontitis （r=0.580, P〈0.05）. CONCLUSIONS： CXCLI6 and CXCR6 may be involved in the development of chronic periodontitis. The expression of CXCL16 and CXCR6 may work coordinately to promote the development of chronic periodontitis.

关 键 词：牙周炎 细胞因子 CXC型趋化因子配体16 CXC型趋化因子受体6 

分 类 号：R781.42[医药卫生—口腔医学]