三阴性年轻乳腺癌患者雄激素受体表达与瘤体大小、淋巴转移的相关性研究  

Relation of triple negative breast cancer androgen receptor expression in young and tumor size,lymph node metastasis

作　　者：李铁灵[1] 郭海峰[1] 孙治国[1] 

机构地区：[1]牡丹江医学院病理教研室,黑龙江牡丹江157011

出　　处：《现代肿瘤医学》2015年第10期1361-1363,共3页Journal of Modern Oncology

基　　金：黑龙江省教育厅科学技术研究项目(编号:12541847)

摘　　要：目的:探讨三阴性年轻乳腺癌患者雄激素受体(AR)表达与乳腺癌瘤体大小及淋巴结转移的相关性。方法:三阴性乳腺癌(TNBC)年轻患者76例,应用免疫组织化学方法检测所有患者的AR表达情况,同时分析AR的表达与患者乳腺癌瘤体大小、淋巴结转移的相关性。结果:76例TNBC患者中,AR表达阳性的患者15例,阳性率为19.74%。AR表达阳性的患者可见细胞核着黄色颗粒,并且随着表达程度的增强,染色细胞也逐渐增多。AR表达阴性的患者则无细胞核着黄色颗粒。合并肿瘤家族史的患者AR阳性率为20.00%,组织学分级G1/G2的患者AR阳性率为66.67%,淋巴结阳性的患者AR阳性率为53.33%,肿瘤瘤体直径在2cm以上的患者AR阳性率为20.00%,合并淋巴结转移的患者AR阳性率为13.33%。结论:TNBC患者AR阳性表达与乳腺癌瘤体大小、淋巴结转移等密切相关,较之AR表达阴性的患者具有更恶性的生物学行为。Objective ：To explore the relation of young breast cancer triple negative breast cancer androgen recep- tor expression and tumor size and lymph node metastasis. Methods ： Triple negative breast cancer 76 younger patients, were detected by immunohistochemistry androgen receptor （ androgen receptor, AR） expression. Results： Of 76 patients with TNBC, AR expression was positive in 15 patients ,the positive rate was 19.74%. AR patients with positive family history of cancer was 20.00% , the positive rate in patients with AR histological grade G1/G2 was 66.67% , positive lymph node -positive patients with AR was 53.33% , the positive rate of tumors in patients with AR tumor 2cm above was 20.00%, with lymph node metastasis in patients with AR - positive rate was 13.33%. Conclusion：In TNBC AR expression was closely related with breast tumor size,lymph node metastasis, has a more malignant biological behavior.

关 键 词：三阴性乳腺癌 雄激素受体 瘤体大小 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]