福达拉滨联合环磷酰胺治疗多毛细胞白血病1例并文献复习  

A case of hairy cell leukemia treated by fludarabine and Cyclophosphamide and literature review

作　　者：朱海霞[1] 李淑晨 燕玮[1] 李旸[1] 张嵘[1] 姚鲲[1] 廖爱军[1] 杨威[1] 

机构地区：[1]中国医科大学附属盛京医院血液科,中国沈阳110022

出　　处：《现代肿瘤医学》2015年第10期1451-1453,共3页Journal of Modern Oncology

摘　　要：目的:探讨多毛细胞白血病(HCL)的临床特点及治疗措施。方法:根据患者的临床表现、骨髓细胞形态学及组织化学染色、免疫分型、电镜检查等进行诊断,采用福达拉滨联合环磷酰胺方案治疗,并综合已有文献简述HCL治疗现状及进展。结果:该例患者为经典型HCL,福达拉滨联合环磷酰胺方案治疗后缓解。结论:HCL患者骨髓涂片发现毛细胞、电镜检查、免疫分型对诊断有重要意义,嘌呤核苷酸类似物对其治疗有较高的缓解率。Objective：To investigate the clinical characteristics of hairy cell leukemia （HCL） and treatment measures. Methods：To diagnose HCL based on the patient＇s clinical characteristics and the morphology, histochemistry staining,immunophenotype, electron microscopy examination of bone marrow cells, treated by Fludarabine and Cyclophosphamide. Results：This patient was diagnoed as classical HCL, and got remission after treated by Fludarabine and Cyclophosphamide. Conclusion： Finding fairy cells by bone marrow smear, electron microscopy examination and im- munophenotype of HCL patients are important to the diagnosis. Meanwhile purine nucleotide analogues have a higher response rate in the treatment.

关 键 词：多毛细胞白血病 福达拉滨 环磷酰胺 诊断 治疗 

分 类 号：R733.7[医药卫生—肿瘤]