鼠神经生长因子对急性脑梗死脑保护的临床观察  

Observation of Clinical Effect of Mouse Nerve Growth Factor in the Treatment of Acute Cerebral Infarction

作　　者：谷巍[1] 毕宝曰[1] 陶金柱[1] 金小仙[1] 赵守法 

机构地区：[1]天津中医药大学一附院针灸科,天津300193

出　　处：《中国医药导刊》2015年第4期356-357,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察鼠神经生长因子(NGF)治疗急性脑梗死的临床效果。方法:将60例急性脑梗死患者随机分为治疗组和对照组,各30例,对照组按照脑梗死基础治疗,治疗组在对照组基础上加用鼠NGF18μg,2周后判断疗效,治疗结束后随访4周。结果:治疗组总有效率93.4%,治疗后神经功能缺损程度评分(NFDS)为(15.37±5.46)分,治疗结束后第4周NFDS为(10.37±5.46)分;对照组总有效率为79.9%,治疗后NFDS为(17.81±6.12)分,治疗结束后第4周NFDS为(15.81±6.12)分。两组比较均有显著性差异。结论:鼠NGF能有效减少急性脑梗死患者的神经功能缺损评分,是一种有效的治疗急性脑梗死的药物。Objective： To observe the clinical effect of mouse nerve growth factor in the treatment of acute cerebral infarction. Methods： 60 patients with acute cerebral infarction were randomly divided into treatment group and control group, each of 30 cases, control group with cerebral infarction therapy, the treatment group in the control group based on the use of mouse nerve growth factor 18μg, to judge the curative effect after 2 weeks, 4 weeks after the end of treatment follow-up. Results： The total effective rate was 93.3% in the treatment group, the degree of neural function defect scores after the treatment （NFDS） for （15.37±5.46） points, fourth weeks alter the end of treatment NFDS was （10.37±5.46）; the control group the total effective rate was 79.9% after treatment, NFDS （17.81±6.12） points, fourth weeks after the end of treatment NFDS （15.81±6.12） %. Were compared between the two groups was significant difference. Conclusion： Mouse nerve growth factor can effectively reduce the neurological deficit score in patients with acute cerebral infarction, is an effective drug in the treatment of acute cerebral infarction.

关 键 词：神经生长因子 急性脑梗死 临床观察 

分 类 号：R743.33[医药卫生—神经病学与精神病学]