急性脑脑卒中超敏C反应蛋白的动态演变及预后观察  

The relationship between the dynamic change of high sensitivity C-reactive protein and prognosis in patients with acute stroke

作　　者：庾建英[1] 刘继新[1] 李春丽[1] 王志丹[1] 李文娟[1] 

机构地区：[1]新疆维吾尔自治区人民医院北院脑科中心,新疆乌鲁木齐830054

出　　处：《蚌埠医学院学报》2015年第4期453-455,共3页Journal of Bengbu Medical College

摘　　要：目的：探讨急性脑卒中患者超敏C反应蛋白（hs-CRP）的动态演变与预后关系。方法：将急性脑卒中患者184例分为缺血性脑卒中102例（缺血组）和出血性脑卒中82例（出血组）。分别于治疗前、治疗后1、2、3、4、6、8周测血hs-CRP水平。并随访1年,观察再发脑卒中情况。结果：2例在发病后2周病死予以剔除。2组患者治疗后1-8周hs-CRP均较治疗前显著降低（P〈0.01）,治疗后2-8周hs-CRP亦均明显低于治疗后1周（P〈0.01）。缺血组患者治疗前后1-8周hs-CRP水平均低于出血组（P〈0.05-P〈0.01）。2组随访观察1年,hs-CRP持续未恢复正常者再发脑血管病率为44.23%,高于hs-CRP恢复正常者的发生率为11.72%（P〈0.01）。结论：急性缺血性脑卒中及急性出血性脑卒中发生后,hs-CRP均明显增高,但急性缺血性脑卒中hs-CRP恢复较急性出血性脑卒中快,hs-CRP持续未恢复者再发脑血管病的概率增高。Objective：To investigate the relationship between the dynamic change of high sensitivity C-reactive protein（ hs-CRP） and prognosis in patients with acute stroke. Methods：One hundred and eighty-four patients with acute stroke were divided into the ischemic stroke group（n=102） and hemorrhagic stroke group（n=82）. The levels of hs-CRP in all patients were measured before treatment and after 1,2,3,4,6 and 8 weeks of treatment. The recurrence of stroke was observed during the 1-year of following up. Results：2 patients died after onset two weeks and were removaled. The levels of hs-CRP in two groups after treatment 1 to 8 weeks compared with prior treatment all decreased significantly（P〈0. 01）. The levels of hs-CRP after treatment 2 to 8 weeks compared with post-treatment 1 week decreased significantly too（P〈0. 01）. The level of hs-CRP in ischemic stroke group on prior treatment and post-treatment 1 to 8 weeks compared with hemorrhagic stroke group all decreased significantly（P〈0. 05-P〈0. 01）. All patients were followed up for 1 year,the recurrence rate of stroke in the patients with abnormal hs-CRP level（44. 23%） was higher than that in the patients with normal hs-CRP level（11. 72%）（P〈0. 01）. Conclusions：The levels of hs-CRP in ischemic stroke group and hemorrhagic stroke group increase significantly,but the recovery of the level of hs-CRP in ischemic stroke group is more quick than that in hemorrhagic stroke group,and the recurrence rate of stroke in the patients with abnormal hs-CRP level increases.

关 键 词：脑血管意外 超敏C反应蛋白 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]