Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries:in vivo and in vitro neuroprotective effect of antihypertensive DDPH  

Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries:in vivo and in vitro neuroprotective effect of antihypertensive DDPH

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作  者:Li Sun Qin Li Wei-ting Wang Yu-hua Chen Lian-jun Guo 

机构地区:[1]Department of Neurology,Wuhan Brain Hospital (General Hospital of the Yangtze River Shipping) [2]Department of Pharmacology,Tongji Medical College of Huazhong University of Science and Technology [3]Department of Pharmacology,Shanghai First People’s Hospital,School of Medicine,Shanghai Jiao Tong University

出  处:《Neural Regeneration Research》2015年第4期589-593,共5页中国神经再生研究(英文版)

基  金:financially supported by grants from the National Natural Science Foundation of China,No.81173038;Yangtz River Navigational Matters Authority of Ministry of Transport of China,No.201210011;Clinical Medicine Research Program of Wuhan Health Planning Commission of China,No.WX14D12

摘  要:1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propane hydrochloride (DDPH) is a novel antihypertensive agent based on structural characteristics of mexiletine and verapamine. We investigated the effect of DDPH on vasodilatation and neuroprotection in a rat model of cerebral ischemiain vivo, and a rabbit model of isolated basilar arteriesin vitro. Our results show that DDPH (10 mg/kg) significantly increased hippocampal blood flowin vivo in cerebral ischemic rats, and exerted dose-dependent relaxation of isolated basilar arteries contracted by histamine or KCl in thein vitro rabbit model. DDPH (3 × 10–5 M) also inhibited histamine-stimulated extracellular calcium inlfux and intracellular calcium release. Our ifndings suggest that DDPH has a vasodilative effect bothin vivo andin vitro, which mediates a neuropro-tective effect on ischemic nerve tissue.1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propane hydrochloride (DDPH) is a novel antihypertensive agent based on structural characteristics of mexiletine and verapamine. We investigated the effect of DDPH on vasodilatation and neuroprotection in a rat model of cerebral ischemiain vivo, and a rabbit model of isolated basilar arteriesin vitro. Our results show that DDPH (10 mg/kg) significantly increased hippocampal blood flowin vivo in cerebral ischemic rats, and exerted dose-dependent relaxation of isolated basilar arteries contracted by histamine or KCl in thein vitro rabbit model. DDPH (3 × 10–5 M) also inhibited histamine-stimulated extracellular calcium inlfux and intracellular calcium release. Our ifndings suggest that DDPH has a vasodilative effect bothin vivo andin vitro, which mediates a neuropro-tective effect on ischemic nerve tissue.

关 键 词:nerve regeneration DDPH cerebral ischemia hippocampus blood flow isolated basilar artery dose-response curve NSFC grant neural regeneration 

分 类 号:R743[医药卫生—神经病学与精神病学]

 

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