泛素蛋白酶体系统在Wnt通路中的研究进展  

The research on the ubiquitin proteasome system in Wnt signal pathway

作　　者：朱剑军[1] 朱晓华[1] 黄平[1] 蒋辉[1] 邓世山[1] 

机构地区：[1]川北医学院基础医学院人体解剖学教研室,四川南充637000

出　　处：《川北医学院学报》2015年第2期255-259,共5页Journal of North Sichuan Medical College

基　　金：四川省教育厅基金项目(13ZB0242);四川省科技厅项目(2012ZZ008)

摘　　要：Wnt信号传导通路是一个由多种分子参与、相互影响、相互制约和协同作用的复杂体系,与细胞信号转导、细胞周期、细胞增殖、细胞凋亡、细胞黏附和迁移以及干细胞的分化潜能等有关。泛素蛋白酶体系统通过调控蛋白活性、亚细胞定位以及蛋白间相互作用等方式在细胞活动中发挥重要的作用。Wnt信号传导通路中β-catenin等关键分子受泛素蛋白酶体途径精密调控。本文就泛素蛋白酶体系统和Wnt通路信号传导相互之间的关系作一综述。Wnt signal pathway is a complex system involved by a variety of molecular which are influenced,restricted and syn-ergied by each other. It is related with the cell signal transduction,cell cycle,cell proliferation,migration and differentiation,apoptosis, adhesion and the potential differentiation ability of stem cells. Ubiquitin proteasome system plays an important role in cell activity through regulated the protein activity,subcellular localization,protein interaction,et al. The key moleculars in Wnt signal pathway,such as β-catenin,is closely regulated by ubiquitin proteasome system. The purpose of this paper is to elaborate the relationship of the Wnt signal pathway with the ubiquitin proteasome system.

关 键 词：泛素蛋白酶 WRIT E3连接酶 Β-CATENIN 

分 类 号：R362[医药卫生—病理学]