mTOR和Survivin在人脑神经胶质瘤中的表达及临床意义  

Expression and clinical significance of m TOR and Survivin in human cerebral gliomas

作　　者：刘桠菲 刘献志[1] 翟广[1] 杨斌[2] 毛冲冲[1] 

机构地区：[1]郑州大学第一附属医院神经外科,河南郑州450052 [2]郑州大学第三附属医院神经外科,河南郑州450052

出　　处：《河南医学研究》2015年第2期4-6,共3页Henan Medical Research

摘　　要：目的探讨m TOR及survivin在不同级别人脑胶质瘤中的表达情况及临床意义。方法采用半定量免疫组化(Envision法)检测35例低级别胶质瘤(Ⅰ、Ⅱ级)、36例高级别胶质瘤(Ⅲ、Ⅳ级)以及10例正常脑组织中m TOR及Survivin的表达情况,并分析m TOR及Survivin的表达情况及相关性。结果与正常脑组织相比,m TOR和Survivin在人脑胶质瘤中的表达均显著增加,在高级别胶质瘤中,两者的阳性表达率显著高于低级别组,m TOR与Survivin的表达呈现相关性(r=0.264,P=0.026<0.05)。结论 m TOR和Survivin在脑胶质瘤中的表达明显增加,m TOR和Survivin可能在神经胶质瘤的发生发展中具有重要的作用。Objective To discuss the expression and clinical significance of mTOR and Survivin in human cerebral glioma. Methods The expression of mTOR and Survivin in 35 glioma tissue samples,36 advanced glioma tissue samples,and 1 0 nor-mal brain tissue samples were detected by the semi -quantitative immunohistochemistry（Envision method）.The expression and correlation between mTOR and Survivin were analyzed.Results The expression levels of mTOR and Survivin in human cerebral glioma tissue samples were significantly higher than normal cerebral tissue samples.The expression rates of mTOR and Survivin in advanced glioma tissue samples were significantly higher than mild and moderate glioma tissue samples.There was a positive correlation between mTOR and Survivin expressions in human glioma（r =0.264,P =0.026 〈0.05）.Conclusion The expres-sion of mTOR and Survivin were significantly increased in human cerebral glioma.mTOR and Survivin may play an important role in the occurrence and development of gliomas.

关 键 词：神经胶质瘤 存活蛋白 信号传导通路 

分 类 号：R365[医药卫生—病理学]