芬吗通内膜准备对多囊卵巢综合征患者冻融胚胎移植周期妊娠率的影响  

Effect of Femoston on pregnancy rate in frozen-thawed embryo transfer cycles of patients with polycystic ovary syndrome

作　　者：赵诗艺 余璐萍[1] 刘英[1] 杨晓葵[1] 张军[1] 余兰[1] 

机构地区：[1]首都医科大学附属北京妇产医院生殖医学科,北京100026

出　　处：《生殖医学杂志》2015年第5期381-385,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金(81471520);国家留学基金(20119110033);北京市自然科学基金(5122015);北京市卫生系统高层次卫生技术人才培养项目(2014-3-075)

摘　　要：目的探讨芬吗通对多囊卵巢综合征(PCOS)患者冻融胚胎移植(FET)周期妊娠率的影响。方法回顾性分析2011年4月至2014年7月在我科接受FET助孕的103例患者(共133个周期),其中PCOS患者55例78个周期,根据内膜准备方案分为:补佳乐人工周期组(38例58个周期),芬吗通人工周期组(17例20个周期);非PCOS患者自然周期组(48例55个周期)作为对照组。比较3组患者的一般情况、基础内分泌激素水平、冷冻胚胎复苏率、移植胚胎数、优质胚胎率、用药时间、用药量、转化日子宫内膜厚度、胚胎种植率、生化妊娠率及临床妊娠率。结果补佳乐组和芬吗通组患者体重指数(BMI)、基础黄体生成素(LH)、血清睾酮(T)均高于自然周期组,差异有统计学意义(P<0.05);补佳乐组用药量为(58.84±36.62)mg,芬吗通组为(58.60±32.65)mg,补佳乐组用药时间为(11.83±4.06)d,芬吗通组为(11.33±2.57)d,两组用药量及用药时间比较均无显著性差异(P>0.05);转化日子宫内膜厚度对照组为(10.32±2.30)mm,较补佳乐组(9.05±0.95)mm及芬吗通组(9.50±1.26)mm,差异有统计学意义(P<0.05),补佳乐组与芬吗通组间比较,无显著性差异(P>0.05);胚胎种植率、生化妊娠率、临床妊娠率3组比较均无统计学差异(P>0.05)。结论 PCOS患者行FET前使用芬吗通进行内膜准备,可获得满意的子宫内膜厚度和妊娠结果。Objective：To study the effect of Femoston on pregnancy rate in frozen-thawed embryo transfer cycles of patients with polycystic ovary syndrome（PCOS）.Methods：The data of 133frozen-thawed embryo transfer（FET）cycles of 103 patients in our department from Apr.2011 to Jul.2014 were retrospectively analyzed.Seventy eight cycles of 55 PCOS patients were divided into two groups according to the protocol of endometrial preparation：Progynova group（58cycle,38patients）and Femoston group（20cycles,17patients）.Fifty five cycles of 48non-PCOS patients were set as control group.The patients＇ general condition,hormone levels,recovery rate of thawed embryo,number of embryos transferred,number of high-quality embryos,days and dosage of Progynova and Femoston used,endometrial thickness on the day on progesterone initiation,implantation rate,biochemical pregnancy rate and clinical pregnancy rate were compared among the three groups.Results：The body mass index（BMI）,basic LH and serum testosterone in Progynova group and Femoston group were significantly higher than those in the control group（P〈0.05）.The days[（11.83±4.06）days vs.（11.33±2.57）days]and dosage[（58.84±36.62）mg vs.（58.60±32.65）mg]in Progynova group used were not significantly different with those in Femoston group（P〉0.05）.The endometrial thickness on the day of progesterone initiation in control group [（10.32±2.30）mm]was significantly higher than that in Progynova group [（9.05±0.95）mm]and Femoston group [（9.50±1.26）mm]（P〈0.05）.There was no significant difference between Progynova group and Femoston group（P〉0.05）.The comparisons of remaining indicators among the three groups were not statistically significant（P〉0.05）.Conclusions：Femoston can be used for preparation prior to frozen-thawed embryo transfer in the artificial cycles of patients with PCOS,which can obtain satisfactory endometrial thickness and pregnancy outcome.

关 键 词：多囊卵巢综合征 冻融胚胎移植 内膜准备 芬吗通 

分 类 号：R[医药卫生]