The Benefit Risk Assessment of Consumption of Marine Species Based on Benefit-Risk Analysis for Foods(BRAFO)-tiered Approach  

作　　者：GAO Yi Xiong ZHANG Hong Xia LI Jing Guang ZHANG Lei YU Xin Wei HE Jia Lu SHANG Xiao Hong ZHAO Yun Feng WU Yong Ning 

机构地区：[1]China National Center for Food Safety Risk Assessment,Key Lab of Food Safety Risk Assessment, Ministry of Health [2]National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention [3]Maternal and Child Care Service Centre of Shiquan County [4]Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood, Zhoushan Municipal Center of Disease Control and Prevention

出　　处：《Biomedical and Environmental Sciences》2015年第4期243-252,共10页生物医学与环境科学（英文版）

基　　金：funded by the National Nature Science of Foundation of China(No.81172675);the National Key Basic Research Program of China(No.2012CB720804)

摘　　要：Objective To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods （BRAFO）-tiered approach. Methods Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury （MeHg）, and dioxin-like compounds （DLCs） in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. Results Based on the BRAFO-tiered approach, reference scenario （no intake） and alternative scenario （intake of specific species of 200 g/week） were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. Conclusion The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.Objective To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods （BRAFO）-tiered approach. Methods Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury （MeHg）, and dioxin-like compounds （DLCs） in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. Results Based on the BRAFO-tiered approach, reference scenario （no intake） and alternative scenario （intake of specific species of 200 g/week） were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. Conclusion The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.

关 键 词：N-3 long-chain polyunsaturated fatty acid Methyl mercury Dioxin-like compound Benefit-Risk Analysis for Foods （BRAFO） Benefit risk assessment 

分 类 号：TS254.1[轻工技术与工程—水产品加工及贮藏工程]