Natural products from Bacillus subtilis with antimicrobial properties  

枯草芽孢杆菌产天然产物及其抗菌性（英文）

作　　者：王涛 梁亚飞 吴绵斌 陈正杰 林建平 杨立荣 

机构地区：[1]Key Laboratory of Biomass Chemical Engineering of Ministry of Education [2]Department of Chemical and Biological Engineering, Zhejiang University [3]Jinhua People's Hospital [4]Zhejiang Key Laboratory of Antifungal Drugs

出　　处：《Chinese Journal of Chemical Engineering》2015年第4期744-754,共11页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(21376215);the National Science and Technology Major Project of New Drug,China(2012ZX09103101-075);the Innovative Research Platform co-constructed by Zhejiang University and Taizhou City,and the Science and Technology Project of Zhejiang Province(2014C33174);the Major State Basic Research Development Program of China(2011CB710803);the National High-Tech Research and Development Program of China(2012AA022302)

摘　　要：Bacillus subtilis produces many chemlcally-dwerse seconaary metaDolltes or interest to chemists ano biologlsts. Based on this, this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins （enzymes）, and non-peptide products. Their structures, bioactive ac- tivities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as well as the overproduction of bioactive com- pounds from B. subtilis by metabolic engineering, ＇~ere also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from 13. subtilis may not only be beneficial in improving yields of the products, but also in helping them to be used in food industry and public medical service on a large-scale.Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists.Based on this,this review gives a detailed overview of the natural components produced by B.subtilis including cyclic lipopeptides,polypeptides,proteins(enzymes),and non-peptide products.Their structures,bioactive activities and the relevant variants as novel lead structures for drug discovery are also described.The challenging effects of fermentation metabolites,isolation and purification,as well as the overproduction of bioactive compounds from B.subtilis by metabolic engineering,were also highlighted.Systematically exploring biosynthetic routes and the functions of secondary metabolites from B.subtilis may not only be beneficial in improving yields of the products,but also in helping them to be used in food industry and public medical service on a large-scale.

关 键 词：Bacillus subtilisAntimicrobialBioseparationDrug design 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]