34例子宫内膜癌合并结直肠癌双原发癌的临床特征及其与Lynch综合征关系分析  

Double primary carcinoma of endometrial carcinoma and colorectal carcinoma:retrospective analysis of 34 cases and discussion of its relationship with Lynch syndrome

作　　者：叶天仪 姚洪文[1] 吴令英[1] 张功逸[1] 张蓉[1] 

机构地区：[1]中国医学科学院肿瘤医院妇瘤科,北京市100021 [2]北京协和医学院

出　　处：《中国肿瘤临床》2015年第8期432-436,共5页Chinese Journal of Clinical Oncology

摘　　要：目的：探讨子宫内膜癌合并结直肠癌双原发癌患者的临床表现、治疗方法及其预后,并分析与Lynch综合征关系。方法：回顾性分析中国医学科学院肿瘤医院34例子宫内膜癌合并结直肠癌双原发癌患者的临床病理资料。结果：34例患者的中位发病年龄为51.5（39--76）岁,64.7%（22/34）有肿瘤家族史,子宫内膜样腺癌占79.4%（27/34）。34例中33例双原发癌患者行手术治疗,19例子宫内膜癌、17例结直肠癌术后行放化疗。2年生存率为84.3%,5年生存率为63.1%。结论：子宫内膜癌合并结直肠癌双原发癌患者多具有肿瘤家族史、发病年龄早、预后与散发型结直肠癌相近,部分患者符合Lynch综合征。Objective： To approach the clinicopathologic characteristics, treatment modalities, and prognosis of the patients with double primary carcinoma of endometrial carcinoma and eolorectal carcinoma and analyze the relationship between this disease and Lynch syndrome. Methods： The clinicopathologic and follow-up data of 34 cases with double primary carcinoma of endometrial carci- noma and colorectal carcinoma treated in Cancer Hospital of Chinese Academy of Medical Sciences were reviewed. Results： The medi- an age of the 34 patients was 51.5 years old （ranging from 39 to 76）. Twenty-two of the total cases （22/34, 64.7%） had tumor family his- tory. The pathologic results indicated that 79.4% （27/34） was endometrioid adenocarcinoma. In the 34 cases, 33 were treated by surgical procedure. Of the 33 cases undergoing surgery, 17 patients with endometrial carcinoma and 19 with colorectal carcinoma received fur- ther adjuvant treatment of chemotherapy and/or radiotherapy. The 2- and 5-year survival rates were 84.3% and 63.1% in the 34 cases, respectively. Conclusion： The age of onset is earlier in the patients with double primary carcinoma than in those with sporadic colorec- tal carcinoma. Some cases have cancer family history, and their survival rates are similar to those of the patients with sporadic colorec- turn carcinoma. Diagnosis of some patients with double primary carcinoma may be in line with Lynch syndrome.

关 键 词：子宫内膜肿瘤 结直肠肿瘤 多原发肿瘤 治疗 预后 

分 类 号：R737.33[医药卫生—肿瘤] R735.34[医药卫生—临床医学]