脉冲染料激光联合外用5%咪喹莫特乳膏治疗微静脉畸形的疗效观察  

Clinical analysis of pulsed dye laser combined with topical 5% Imiquimod Creamtreatment of port wine stains

作　　者：周颖华[1] 郝思辉 倪小丽[1] 王路[1] 

机构地区：[1]南京医科大学友谊整形外科医院皮肤科,江苏南京210000 [2]南京奇致整形医院,江苏南京210000

出　　处：《中国美容医学》2015年第7期49-52,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:通过对微静脉畸形患者施行脉冲染料激光联合外用5%咪喹莫特乳膏治疗,来观测此联合疗法的临床使用情况,评估其疗效。方法:80例微静脉畸形患者,随机分为两组。联合组:40例,采用脉冲染料激光联合外用5%咪喹莫特乳膏治疗;对照组:40例,采用普通脉冲染料激光治疗;治疗后1个月、4个月、8个月和12个月进行随访,通过观测患者皮损颜色变化情况并计算有效率,测试治疗部位的血红蛋白指数整体评估治疗效果,最后采用计算机SPSS12.0软件进行统计学分析。结果:联合组治疗后的1、4、8、12月血红蛋白指数较治疗前低,在随访期基本维持稳定,各血红蛋白指标较对照组均有统计学意义(P<0.05),联合组有效率为87.5%,高于对照组的77.5%。结论:脉冲染料激光联合外用5%咪喹莫特乳膏治疗微静脉畸形具有持续性好,复发率低等优点,有很好的临床应用前景。Objective Through the implementation of pulsed dye laser in patients with nevus flammeus with topical 5% mi sinensis mulder cream therapy,to observe the clinical use of combination therapy,evaluate the curative effect. Methods 80 patients to the hospital treatment of nevus flammeus,to use ordinary pulsed dye laser treatment of the control group and the pulsed dye laser in combination with topical 5% mi sinensis mott cream 1 months,4 months after treatment,8 months and 12 months follow-up,by observing patients with skin color changes and computational efficient,and test the therapeutic part of hemoglobin index for overall evaluation of treatment effect, finally USES the computer SPSS12.0 software for statistical analysis. Results The observation group after treatment of 1,4,8,12 month hemoglobin index was lower than those of before treatment,the basic stability in the follow-up,the hemoglobin index than the control group were statistically significant（P〈0.05）.The combined treatment group effective rate was 87.5%,higher than 77.5% in the control group. Conclusion The pulsed dye laser in combination with topical 5% mi sinensis mott cream in the treatment of nevus flammeus has advantages of good continuity,low recurrence rate of curative effect,has good clinical application prospects.

关 键 词：脉冲染料激光 咪喹莫特 微静脉畸形 疗效 

分 类 号：R732.2[医药卫生—肿瘤]