Notch信号通路在脑生发区神经干细胞维持与神经再生中的作用  

The Role of Notch Signaling Pathway in Maintenance of Neural Stem Cells and Neurogenesis in Brain Germinal Zone

作　　者：沈建英[1,2] 林玲[2] 郑志竑[2] 

机构地区：[1]福建中医药大学中医证研究基地,福州350122 [2]福建医科大学神经生物学中心,福州350122

出　　处：《中国细胞生物学学报》2015年第4期588-593,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81302886);福建省自然科学基金(批准号:2013J01336;2013J01372)资助的课题~~

摘　　要：成年神经再生在各种脑损伤、神经系统变性疾病的修复中发挥了重要的作用。在啮齿类和灵长类动物脑中,其主要发生在侧脑室(lateral ventricle,LV)的脑室下区(subventricular zone,SVZ)和海马齿状回(dentate gyrus,DG)颗粒下区(subgranular zone,SGZ)。神经干细胞(neural stem cells,NSCs)的增殖与分化之间的平衡调控是成年神经再生的重要机制。成年神经再生过程包含几个阶段,每个阶段均受到多种内源性和外源性因素的调节。Notch信号通路在成年NSCs的维持中发挥了重要的作用。该文将对Notch信号通路在脑生发区NSCs的维持与神经再生中的作用机制及其研究进展进行综述。Adult neurogenesis is important for various cerebral injury and neurodegenerative disease. In the rodents and primates adult brain, it mainly occurs in the subventricular zone（SVZ） of the lateral ventricles（LV） and subgranular zone（SGZ） of the hippocampal dentate gyrus（DG）. Coordinated proliferation and differentiation of adult neural stem cells（NSCs） is an important mechanism of adult neurogenesis. Adult neurogenesis process consists of a series of stages and each stage is discretely regulated by a variety of intrinsic and extrinsic factors. Notch signaling plays an important role in maintenance of the reservoir of adult NSCs. In this review, we will summarize the important role of Notch signaling for maintaining NSCs and neurogenesis in the adult SVZ and SGZ.

关 键 词：成年神经再生 脑生发区 NOTCH信号通路 神经干细胞 

分 类 号：R741[医药卫生—神经病学与精神病学]