微乳头型单纯黏液癌伴浸润性微乳头状癌的临床病理观察  

Clinicopathological observation of breast micropapillary pure mucinous carcinoma combined with invasive micropapillary carcinoma

作　　者：徐明[1] 叶曼娜 汪成[2] 叶辉[3] 

机构地区：[1]上海市黄浦区中心医院病理科,上海200002 [2]上海市黄浦区中心医院乳腺外科,上海200002 [3]上海市黄浦区中心医院外科,上海200002

出　　处：《上海交通大学学报（医学版）》2015年第4期549-553,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市医学重点专科建设项目(ZK2012A13)~~

摘　　要：目的探讨微乳头型单纯黏液癌(MPPMC)与MPPMC伴有乳腺浸润性微乳头状癌(IMPC)病例的临床病理特点。方法收集8例MPPMC和5例MPPMC伴IMPC病例的临床病理资料,对组织形态、免疫表型及临床特点进行分析。结果 5例MPPMC伴IMPC均见2种形态之间的移行过渡,微乳头周围黏液逐渐消失,形成IMPC。在MPPMC向IMPC转化后癌组织Ki-67的表达率显著增高。MPPMC组淋巴结转移率仅为12.5%,而MPPMC伴IMPC组淋巴结转移率高达80%。淋巴结转移灶中以IMPC形态为主。结论乳腺MPPMC与IMPC可能处于同一肿瘤谱系。MPPMC伴IMPC生物学行为更差,治疗原则要参照IMPC。Objective To explore the clinicopathological features of micropapillary pure mucinous carcinoma（ M PPM C） and M PPM Ccombined with invasive micropapillary carcinoma（ IM PC）.Methods Clinical pathological data of 8 cases of M PPM Cand 5 cases of M PPM Ccombined with IM PCwere collected and the histological morphology, immune phenotypes, and clinical features were analyzed.Results Transitional regions were observed in 5 cases of M PPM Ccombined with IM PC.The mucus around the micropapillary gradually disappeared and formed IM PC.The expression of Ki-67 in cancer tissues significantly increased after the transformation of M PPM Cto IM PC.The rate of lymph node metastasis of the M PPM Cgroup was only12.5%, while that of the M PPM Ccombined with IM PCgroup was 80%.The main type of cancer in lymph node metastases was IM PC.Conclusion Breast M PPM Cand IM PCmay be in the same tumor lineages.The biological behavior of M PPM Ccombined with IM PCis more serious.The treatment of M PPM Ccombined with IM PCshould reference that of IM PC.

关 键 词：乳腺癌 微乳头状 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]