家族性渗出性玻璃体视网膜病变相关的孔源性视网膜脱离患者对侧眼临床特征  

Clinical Characteristics of Contralateral Fellow Eyes in Patients with Familial Exudative Vitreoretinopathy-associated Rhegmatogenous Retinal Detachment

作　　者：杨宇[1] 袁敏而[1] 于珊珊[1] 闫宏[1] 李加青[1] 吕林[1] 丁小燕[1] 

机构地区：[1]中山大学中山眼科中心//眼科学国家重点实验室,广东广州510060

出　　处：《中山大学学报（医学科学版）》2015年第2期313-316,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81470645)

摘　　要：【目的】研究家族性渗出性玻璃体视网膜病变相关的孔源性视网膜脱离(FEVR相关的RRD)患者的对侧眼的临床特征。【方法】对一组10~30岁发生孔源性视网膜脱离(RRD)的患者进行回顾性研究,对其中最终确诊为FEVR相关的RRD的占有比及对侧眼临床特征进行分析。【结果】共纳入2013年10月至2014年7月接诊的RRD患者共109例110眼,其中FEVR相关的RRD占同期同年龄组RRD患者总数的20.18%(22/109),且与年龄密切相关。10~20岁患者中FEVR相关的RRD占总人数的43.24%。FEVR相关RRD患者平均年龄为17(S=5)岁,对侧健眼屈光范围为+4.5D^-8.0D,近视者居多。其中4眼(19.05%)为高度近视,屈光度大于-6 D,12眼(57.14%)为轻中度近视,屈光度位于-0.75 D至-6 D之间。对侧眼Log MAR为-0.1至1.2不等,多数视力正常,仅2例BCVA(Log MAR)大于0.5。后极部眼底表现多为正常,周边部视网膜均见异常,如无血管区、视网膜变直、血管分支增多及血管渗漏,其他还可表现为血管袢、新生血管生成、视网膜嵴样改变、格子样变性、周边部萎缩孔、视网膜浅脱离等。【结论】家族性渗出性玻璃体视网膜病变相关的孔源性视网膜脱离是青少年人群孔源性视网膜脱离的主要原因之一,多为双眼发病,详细检查对侧眼至关重要,应及时处理视网膜裂孔及新生血管等并发症。【Objective】To investigate the clinical characteristics of the fellow eyes in the patients with familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment（FEVR-associated RRD）. 【Methods】 All patients, ranged from 10 to30 years old, had clinically diagnosed with rhegmatogenous retinal detachment（RRD） were enrolled. The proportion and clinical features of the contralateral eyes inpatients with FEVR-associated RRD were evaluated. 【Results】 110 eyes in 109 patients was clinical diagnosed with RRD, and the proportion of FEVR-associated RRD in the total RRD patients at the same period and same age was20.18%（22 / 109）, while in the 10-to-20 year-old age group, the proportion reached up to 43.24%. The average age of FEVRassociated RRD was 17（S = 5） years. As for the refractive status, the scopes of refraction in the contralateral eye were ＋4.5 D to-8.0D and most were myopic. Four eyes（19.05%） were over-6.0D, twelve eyes（57.14%） were within-0.75Dto-6.0D, and six eyes were within the range of ＋ 2.0D to-0.75 D. The best corrected visual acuity（BCVA） of Log MAR units was normal in most patients ＇contralateral eyes, and only in 2 eyes the BCVA（Log MAR） was over 0.5. Most of the posterior retinal manifestations were normal,while the abnormalities in the peripheral retinal were performed in all patients, including incomplete vascularization, retinal straight,branching of vessels and vascular exudation. Besides, the vascular loop, neovascularization, retinal ridge, lattice degeneration,atrophy hole and Partial retinal detachment were also performed. 【Conclusions】 FEVR-associated RRD is one of the main causes of the juvenile hegmatogenous retinal detachment. Bilateral onset is the main characteristic. The detailed examination on the contralateral eyes is crucial and helpful.

关 键 词：家族性渗出性玻璃体视网膜病变 孔源性视网膜脱离 临床特征 

分 类 号：R774.12[医药卫生—眼科]