氨磺必利治疗首发精神分裂症疗效观察  

Effect of amisulpride on first-episode schizophrenia

作　　者：樊园媛 张新风[1] 肖寒[1] 郭伟[1] 刘胜皇[1] 涂哲明[1] 

机构地区：[1]荆州市精神卫生中心三病区,湖北荆州434000

出　　处：《中华实用诊断与治疗杂志》2015年第5期513-515,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨氨磺必利治疗首发精神分裂症的临床疗效及其对患者糖脂代谢的影响。方法首发精神分裂症患者80例随机分为治疗组和对照组各40例,治疗组给予氨磺必利治疗,对照组给予利培酮治疗,2组疗程均为8周。分别于治疗前及治疗第1、2、4、8周应用阳性与阴性症状量表(Positive and Negative Syndrome scale,PANSS)及治疗时出现的症状量表(Treatment Emergent Symptom Scale,TESS)评定疗效和不良反应,并测定2组治疗前及治疗8周后体质量、空腹血糖(fasting plasma glucose,FPG)、总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)。结果治疗组总有效率(87.5%)与对照组(90.0%)比较差异无统计学意义(P>0.05);治疗2、4、8周后,治疗组阴性症状评分分别为20.7±4.8、16.2±4.5、12.5±5.1,对照组分别为22.8±4.4、20.8±4.1、16.3±5.3,2组比较差异有统计学意义(P<0.05);2组间各时点PANSS总分,阳性症状评分及精神病理评分比较差异无统计学意义(P>0.05);治疗组不良反应TESS评分(1.99±0.21)低于对照组(2.20±0.20)(P<0.05);治疗组治疗前后TC、TG、LDL-C、HDL-C、FPG及体质量比较差异无统计学意义(P>0.05),对照组治疗后TC[(4.58±0.88)mmol/L]、TG[(1.39±0.76)mmol/L]、LDL-C[(2.65±0.79)mmol/L]及体质量[(62.61±12.55)kg]较治疗前[TC(3.85±0.57)mmol/L、TG(1.12±0.38)mmol/L、LDL-C(2.11±0.41)mmol/L、体质量(57.09±11.36)kg]增高(P<0.05),且高于治疗组治疗后[TC(4.19±0.84)mmol/L、TG(1.11±0.41)mmol/L、LDL-C(2.18±0.70)mmol/L、体质量(57.43±10.30)kg]。结论氨磺必利治疗首发精神分裂症的疗效与利培酮相当,在阴性症状改善上优于利培酮,对体质量和糖脂代谢影响小,且不良反应轻。Objective To explore the effect of amisulpride on first-episode schizophrenia and its influence on glucose and lipid metabolism.Methods Eighty patients with first-episode schizophrenia were randomly divided into treatment group and control group,with 40 patients in each group.Treatment group received amisulpride and control group received risperidone for 8 weeks.The effect and adverse reaction were evaluated with Positive and Negative Syndrome Scale（PANSS）and Treatment Emergent Symptom Scale（TESS）before treatment and after 1-,2-,4-and 8-week treatment.And the body mass,fasting plasma glucose（FPG）,total cholesterol（TC）,triacylglycerol（TG）,high density lipoprotein-cholesterol（HDL-C）and low density lipoprotein-cholesterol（LDL-C）were measured before and after 8-week treatment.Results After 8-week treatment,there was no significant difference in the total effective rate between treatment group（87.5%）and control group（90.0%）（P0.05）.The Negative Symptom Scores were 20.7±4.8,16.2±4.5and 12.5±5.1in treatment group,significantly different from those in control group（22.8±4.4,20.8±4.1,16.3±5.3）after 2-,4-and 8-week treatment（P0.05）.There were no significant differences in PANSS,Positive Symptom Scores and Mental Pathological Scores between two groups（P0.05）.TESS score was significantly lower in treatment group（1.99±0.21）than that in control group（2.20±0.20）（P 0.05）.There were no significant differences in TC,TG,LDL-C,HDL-C,FPG and body mass before treatment and after 8-week treatment in treatment group（P0.05）.TC,TG,LDL-C and body mass were higher after 8-week treatment（（4.58±0.88）mmol/L,（1.39±0.76）mmol/L,（2.65±0.79）mmol/L,（62.61±12.55）kg）than those before treatment（（3.85±0.57）mmol/L,（1.12±0.38）mmol/L,（2.11±0.41）mmol/L,（57.09±11.36）kg）in control group,and were higher than those after treatment in treatment group（（4.19±0.84）mmol/L,（1.11±0.41）mmol/L,（2.18±0.70）mmol/L,（57.43±10.30）kg�

关 键 词：精神分裂症 首发 氨磺必利 临床疗效 糖脂代谢 

分 类 号：R749.3[医药卫生—神经病学与精神病学]