乳腺癌骨转移分子机制研究进展  

Research progress on the molecular mechanism of breast cancer bone metastasis

作　　者：曾慧娟[1] 王少华[1] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)解放军普通外科研究所,南京医学博士研究生210002

出　　处：《医学研究生学报》2015年第4期432-436,共5页Journal of Medical Postgraduates

基　　金：国家重点基础研究发展计划(973计划)(2014CB744500)

摘　　要：乳腺癌是女性最常见的恶性肿瘤之一,骨为其最易发生转移的部位。一旦发生骨转移,患者预后及生活质量明显下降,然而目前仍缺乏有力证据证实的、能够应用于临床的特异性诊疗手段。因此,迫切需要从其分子机制入手,寻找新的分子靶点。文中就乳腺癌骨转移在基因、蛋白及miRNA3个层面机制的研究进展作一综述,并阐述了乳腺癌骨转移动物模型的建立方法。Breast cancer is one of the most common malignant tumors in women. Bone is commonly affected in the context of metastatic breast cancer.Once bone metastasis happens, patient would experience poor prognosis and impaired quality of life.However, there is a lack of approaches for more sensitive and specific diagnosis and treatments for breast cancer bone metastasis.Thus, it is im-perative to find new treatment target from molecular mechanism.In this paper, we review the current research progress on the molecular mechanism from several levels including gene profile, proteins and microRNAs.We also review the establishment of animal models of breast cancer bone metastasis.With the achievements acquired in the completed or undergoing researches on breast cancer bone metasta-sis, we hope the finding of the optimal diagnostic and therapeutic targets could lead the breast cancer research into a new era.

关 键 词：乳腺癌骨转移 分子机制 动物模型 

分 类 号：R737.9[医药卫生—肿瘤]