不同脂肪乳剂对急性坏死性胰腺炎患者肝肾功能及脂肪代谢影响的前瞻性研究  被引量:5

Effects of different types of triglycerides on hepatic and renal function and lipometabolism of patients with acute necrotizing pancreatitis: a prospective study

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作  者:陈继业[1] 何蕾[1] 刘志伟[1] 蔡守旺[1] 董家鸿[1] 

机构地区:[1]解放军总医院肝胆外科医院全军肝胆外科研究所,北京100853

出  处:《中华消化外科杂志》2015年第5期376-380,共5页Chinese Journal of Digestive Surgery

基  金:国家科技支撑计划课题(2012BA106801)

摘  要:目的 探讨结构脂肪乳与物理混合的中长链脂肪乳对急性坏死性胰腺炎(ANP)患者肝肾功能及脂肪代谢的影响.方法 选取2012年1月至2014年6月解放军总医院收治的30例ANP患者进行前瞻性研究.采用随机、双盲对照研究方法,通过随机数字表法将入组患者分为试验组和对照组,每组15例.两组患者接受≥5 d等氮等热量肠外营养支持治疗.其中试验组采用结构脂肪乳,对照组采用物理混合的中长链脂肪乳.在行营养支持治疗前、治疗后1、3、5 d抽取患者静脉血,测定ALT、AST、GGT、ALP、Cr、BUN、TG和TC水平.正态分布的计量资料采用(x)±s表示,偏态分布的计量资料采用M(范围)表示,采用独立样本t检验或重复测量方差分析,计数资料采用χ2检验.结果 筛选出符合研究条件患者共30例.两组患者ALT、AST、GGT、ALP、Cr、BUN、TG、TC水平于营养支持治疗前、治疗后1、3、5d内在一定范围内变化.试验组患者ALT、AST、GGT、ALP、Cr、BUN、TC分别由治疗前29.0 U/L、25.4 U/L、83.2 U/L、(193±115) U/L、(124±97)μmol/L、(8±6) mmol/L、(2.4±1.1)mmol/L变化为治疗后5d的29.4 U/L、33.0 U/L、77.7 U/L、(172±74) U/L、(117±103) μmol/L、(8±5)mmol/L、(2.3±1.0) mmol/L;对照组患者上述指标分别由治疗前23.8 U/L、22.9 U/L、96.2 U/L、(148±108) U/L、(82±57) μmol/L、(9±7)mmol/L、(2.5 ±0.7) mmol/L变化为21.3 U/L、24.5 U/L、127.4 U/L、(179±126) U/L、(80±54) μmol/L、(10±6) mmol/L、(2.4±0.8)mmol/L.两组各指标营养支持治疗前后变化趋势比较,差异无统计学意义(F=0.647,1.186,0.282,0.553,0.862,0.182,0.369,P>0.05).试验组患者TG由治疗前(1.5±0.6) mmol/L变化为治疗后5d的(1.5±0.7) mmol/L,其中治疗后l dTG水平较治疗前升高,至治疗后3、5 dTG水平恢复到治疗前水平;对照组患者TG治疗前(1.5±0.6) mmol/L变化为治疗后5d的(2.4±0.6) mmObjective To investigate the effects of structured triglyceride (STG) and physical mixed medium chain/long chain triglycerides (MCT/LCT) on hepatic and renal function and lipometabolism of patients with acute necrotizing pancreatitis (ANP).Methods The clinical data of 30 patients with ANP who were admitted to the PLA General Hospital between January 2012 and June 2014 were prospectively analyzed.A double-blind,randomized,controlled study was performed in 30 patients who were allocated into the experimental group (15 patients received STG) and the control group (15 patients received physical mixed MCT/LCT).All the patients received isometrical nitrogen and isocaloric parenteral nutrition more than 5 days.The levels of alanine transaminase (ALT),aspartate transaminase (AST),glutamyl-transpeptidase (GGT),alkaline phosphatase (ALP),creatinine (Cr),blood urea nitrogen (BUN),triglyceride (TG) and total cholesterol (TC) were assayed before nutritional support treatment and at day 1,3 and 5 after nutritional support therapy.The measurement data with normal distribution was presented as (x) ± s.The skew distribution data were described as M (range).The comparison between groups were evaluated with an independent sample t test or one-way ANOVA.The count data were analyzed using the chi-square test.Results A total of 30 patients were screened for eligibility.The levels of ALT,AST,GGT,ALP,Cr,BUN,TG and TC were changed within a certain range at day 1,3 and 5 after nutritional support treatment.The levels of ALT,AST,GGT,ALP,Cr,BUN and TC before treatment and at day 5after treatment were changed from 29.0 U/L,25.4 U/L,83.2 U/L,(193 ± 115) U/L,(124 ± 97) μmol/L,(8±6)mmol/L and (2.4±1.1)mmol/L to 29.4 U/L,33.0 U/L,77.7 U/L,(172±74)U/L,(117 ±103)μmol/L,(8 ± 5) mmol/L and (2.3 ± 1.0) mmol/L in the experimental group,and from 23.8 U/L,22.9 U/L,96.2 U/L,(148 ± 108) U/L,(82 ± 57) μmol/L,(9 ± 7) mmol/L and (2.5 ± 0.

关 键 词:急性坏死性胰腺炎 营养支持治疗 结构脂肪乳 脂肪代谢 

分 类 号:R576[医药卫生—消化系统] R459.3[医药卫生—内科学]

 

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