Twist和VEGF在上皮性卵巢癌中的表达  

Expressions of Twist and VEGF in epithelial ovarian cancer

作　　者：杨丽娜[1,2] 吴娟[1] 赵静[1] 戴斌[3] 杨红[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032 [2]中国兵器工业卫生研究所,陕西西安710065 [3]第四军医大学西京医院肝胆胰脾外科,陕西西安710032

出　　处：《西安交通大学学报（医学版）》2015年第3期341-344,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助(No.81272202)~~

摘　　要：目的探讨Twist及VEGF在卵巢癌发生发展中的作用及其与临床病理特征的关系。方法采用免疫组化SP法检测Twist及VEGF蛋白在80例上皮性卵巢癌组织中的表达情况,并选取10例正常卵巢组织作为对照。结果在80例上皮性卵巢癌组织中,Twist及VEGF蛋白均表达于细胞质中,其阳性表达率分别是85%(68/80)、86.25%(69/80),明显高于正常卵巢组织,差异均有统计学意义(P<0.01)。Twist和VEGF表达与上皮性卵巢癌临床分期、病理分级、淋巴结转移相关(P<0.01),与年龄、病理类型无关(P>0.05)。在上皮性卵巢癌中,Twist与VEGF蛋白的表达呈正相关(r=0.646,P<0.01)。结论 Twist及VEGF在上皮性卵巢癌的发生、发展和侵袭中有重要作用。Objective To investigate the role of Twist and vascular endothelial growth factor （VEGF）in the development of epithelial ovarian cancer and their relationship with clinical pathological features.Methods The expressions of Twist and VEGF were detected by immunohistochemical staining （SP）method in 80 cases of epithelial ovarian cancer and 10 paired cases of normal ovarian tissue.Results In the 80 cases of ovarian cancer tissues,the positive expression rate of Twist and VEGF in epithelial ovarian cancer was 85% and 86.25%,respectively,which were remarkably higher than those in normal ovarian tissues （P 〈0.01）.The expressions of Twist and VEGF were closely associated with clinical stages,pathological grades and lymph node metastasis,but not correlated with age or pathological patterns （P 〉0.05）.There was a significant correlation between the expressions of Twist and VEGF in epithelial ovarian cancer （r =0.646,P 〈0.01）.Conclusion The high expressions of Twist and VEGF may play a potential role in the occurrence,development and invasion process of epithelial ovarian cancer.

关 键 词：卵巢癌 TWIST 血管内皮生长因子 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]