改变时间分辨力对宫颈癌螺旋CT灌注及辐射剂量的影响  

Effects of changing temporal resolution of spiral computed tomography on perfusion of cervical cancer and radiation dose

作　　者：曹振东[1] 王胜林[1] 李春辉[2] 王淑贤[1] 柳逢春[1] 宋雪[1] 贾丽美[1] 

机构地区：[1]承德医学院附属医院CT科,河北承德067000 [2]承德医学院附属医院病理科,河北承德067000

出　　处：《西安交通大学学报（医学版）》2015年第3期387-390,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：河北省科技厅指令课题资助(No.12276104D-20)~~

摘　　要：目的研究不同时间分辨力对宫颈癌CT灌注参数以及灌注曲线的影响。方法对10例经临床确诊的宫颈癌患者行CT灌注扫描,原始数据采样时间分辨力为0.75s,然后将原始数据按不同时间分辨力进行分组,分别为1.5、2.25、3、3.75、4.5、5.25、6s组(实验组),各组按照相同的数学模型及相同部位感兴趣区(ROI),分别计算灌注参数血流量(BF)、血容量(BV)、平均通过时间(MTT)、渗透系数(PS)并与原始数据组(对照组)进行比较分析。结果 BF与MTT对时间分辨力的改变较敏感,当时间分辨力为3s时,即产生显著影响;PS与BV对时间分辨力变化的敏感性较差,当时间分辨力为4.5s时,对PS产生显著影响,当时间分辨力为5.25s时,才对BV产生显著影响。结论改变时间分辨力会导致灌注曲线及灌注参数发生相应改变,但在不影响诊断目的前提下,适当减低宫颈癌CT灌注扫描的时间分辨力(循环扫描时间≤2.25s)可以有效降低辐射剂量。Objective To study the effects of different temporal resolution of spiral computed tomography （CT）on perfusion parameters and perfusion curve of cervical cervical cancer.Methods Ten cases of cervical cancer were clinically confirmed with CT perfusion scanning.The original data were acquired using temporal resolution of 0.75 s.Then the original data were grouped according to different temporal resolution,namely,1.5 s group,2.25 s group,3 s group,3.75 s group,4.5 s group,5.25 s group,and 6 s group （experiment group）. According to the same mathematical model and ROI of the same part,perfusion parameters （BF,BV,MTT,and PS）in each group were calculated respectively and compared with the original data.Results BF and MTT were relatively sensitive to the change of temporal resolution.When the temporal resolution was 3 s,it had a significant impact.PS and BV were not so sensitive to the change of temporal resolution.Temporal resolution of 4.5 s had a significant effect on PS. There was a significant effect on BV until the temporal resolution was 5.25 s. Conclusion Changing the temporal resolution will lead to corresponding changes of perfusion curve and perfusion parameters.Under the premise that it does not affect the diagnosis,properly decreasing temporal resolution （circu-lar scanning temporal ≤2.25 s）of CT perfusion scanning of cervical cancer can reduce the radiation dose effectively.

关 键 词：宫颈癌 时间分辨力 灌注 时间密度曲线 数学模型 CT 辐射剂量 

分 类 号：R737.33[医药卫生—肿瘤] R445.3[医药卫生—临床医学]