转录因子FOXA1与前列腺癌恶性程度及进展相关性研究  

Correlation of FOXA1 with the malignancy and progression of prostate cancer

作　　者：冯伟[1] 张红宾[2] 王养民[2] 胡巨龙[1] 

机构地区：[1]第四军医大学西京医院泌尿外科,陕西西安710032 [2]兰州军区兰州总医院泌尿外科,甘肃兰州730050

出　　处：《中华男科学杂志》2015年第5期414-419,共6页National Journal of Andrology

摘　　要：目的:探讨FOXA1与前列腺癌(PCa)临床分期、组织学分级及去势抵抗性前列腺癌(CRPC)的关系。方法:收集前列腺癌患者(35例)、良性前列腺增生(BPH)患者(21例)前列腺组织病理切片,应用免疫组化方法检测FOXA1和Ki-67的表达情况,进一步分析该分子阳性表达率与肿瘤临床分期、Gleason评分和CRPC的相关性。结果:PCa患者前列腺组织中FOXA1表达率明显高于BPH患者(100%vs 71.4%,P<0.01),FOXA1的表达阳性率与Ki-67表达阳性率正相关(P<0.001),与CRPC无明显相关性(P=0.391),但与Gleason评分(P=0.027)和肿瘤临床分期(P=0.002)相关。结论:FOXA1在前列腺癌组织中表达阳性率增高,晚期前列腺癌最高。Objective：To study the relationship of the expression of FOXA1 in the prostate cancer（PCa） tissue with the Gleason score and clinical staging of PCa and with castration-resistant PCa（ CRPC）.Methods：Using the immunohistochemical method,we detected the expressions of FOXA1 and Ki-67 in the pathological sections of 35 cases of PCa and 21 cases of benign prostatic hyperplasia（ BPH）.Then we analyzed their correlation with the Gleason score and TNM staging of PCa and that with CRPC.Results：The positive expression of FOXA1 was significantly higher in the PCa than in the BPH tissue（ P 〈0.001） and was positively correlated with that of Ki-67（ P 〈0.001） as well as with the Gleason score（ P = 0.027） and clinical staging of PCa（ P = 0.002）,but showed no correlation with CRPC（ P = 0.391）.Conclusion：The positive expression of FOXA1 is increased in PCa,most significantly in the advanced stage of the tumor.

关 键 词：前列腺癌 FOXA1 肿瘤 基因 免疫组化 

分 类 号：R737.25[医药卫生—肿瘤]