伴中央颞区棘波的儿童良性癫痫患者注意网络研究  

Attention networks in benign epilepsy children with centrotemporal spikes

作　　者：汪晓翠[1] 杨斌[1] 沈丽伟[1] 杨广娥[1] 叶小飞[1] 张志明[1] 

机构地区：[1]安徽医科大学儿科临床学院安徽省儿童医院神经内科,合肥230051

出　　处：《中华神经科杂志》2015年第5期406-410,共5页Chinese Journal of Neurology

摘　　要：目的 研究伴中央颞区棘波的儿童良性癫痫（BECT）患者注意网络的损害情况.方法 运用Fan设计的注意网络测试工具,对已确诊的75例BECT患儿（BECT组）和75名健康儿童（对照组）分别进行注意网络检查.结果 BECT组注意网络检查正确率（95.77％±5.63％）低于对照组（98.55％±1.80％）,差异有统计学意义（t =4.063,P＜0.05）;BECT组注意网络检查总平均反应时[（946.87±199.82） ms]显著长于对照组[（729.00±146.75） ms],差异有统计学意义（t=-7.611,P ＜0.05）.BECT组的定向网络效率[29（12,56） ms]低于对照组[51（21,78） ms],差异有统计学意义（Z=-2.771,P=0.006）;执行功能网络效率[80（50,105） ms]高于对照组[57（25,88） ms],差异有统计学意义（Z=-2.146,P=0.032）;两组间警觉网络效率差异无统计学意义（P＞0.05）.非条件Logistic回归分析结果显示,发病年龄是影响患儿注意网络检查正确率和总平均反应时的相对独立危险因素（分别为OR=1.830,95％ CI1.193～2.807,P=0.006和OR=1.635,95％ CI 1.176～2.275,P=0.003）.结论 BECT患儿存在注意网络损害,且癫痫发病年龄是影响患儿注意网络水平的危险因素.Objective To investigate the characteristics of attention networks impairment in benign epilepsy children with centrotemporal spikes.Methods The attention network test was performed in benign epilepsy children with centrotemporal spikes （n =75） and normal controls （n =75） on the efficiency of three anatomically defined attention networks：alerting,orienting,and execrtive control.Results The correct rate of attention network test was significantly lower in benign epilepsy children with centrotemporal spikes （95.77% ± 5.63%） than that in normal controls （98.55% ± 1.80% ; t =4.063,P 〈 0.05）.The total average response time was significantly longer in benign epilepsy children with centrotemporal spikes （（946.87 ± 199.82） ms） than that in normal controls （（729.00 ± 146.75） ms ; t =-7.611,P 〈 0.05）.The orienting network effect （29 （12,56）ms） was lower in benign epilepsy children with centrotemporal spikes than in normal controls （51 （21,78） ms; Z =-2.771,P =0.006）.The executive control network effect was higher in benign epilepsy children with centrotemporal spikes （80 （50,105） ms） than in normal controls （57 （25,88） ms; Z =-2.146,P =0.032）.However,the difference in alerting network effects between the two groups was not statistically significant （P 〉 0.05）.Logistic regression analysis showed that the age on onset of the disease was an independent risk factor for the correct rate of attention network test and the total average response time （OR =1.830,95% CI 1.193-2.807,P =0.006 ; OR =1.635,95% CI 1.176-2.275,P =0.003）.Conclusions The benign epilepsy children with centrotemporal spikes have impairment of attention networks.The age on onset of the disease has a significant impact on the attention of children with rolandic epilepsy.

关 键 词：注意网络 伴中央颞区棘波的儿童良性癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]