细胞自噬与心血管疾病中炎症反应的相关性  

Relationship of autophagy and inflammatory processes of cardiovascular disease

作　　者：杨扬[1] 赵美[1] 赵铭[1] 臧伟进[1] 

机构地区：[1]西安交通大学医学部基础医学院药理学系,陕西西安710061

出　　处：《心脏杂志》2015年第3期340-343,共4页Chinese Heart Journal

基　　金：国家自然科学基金重大国际(地区)合作项目资助(81120108002);高等学校博士学科点专项科研基金优先发展领域课题资助(20130201130008);陕西省自然科学基金项目资助(2012JZ4001)

摘　　要：细胞自噬既是保守的细胞防御机制,也是程序性细胞死亡(即调亡)机制,其可维持细胞自身内环境的稳态。心血管疾病多伴有炎症反应并与细胞自噬密切相关。新近研究表明:一方面,自噬可以通过清除堆积蛋白和保持线粒体稳态对抗心血管疾病的炎症反应,此效应可能与抑制炎症小体以及钙蛋白酶依赖的白介素-1α的活性有关;另一方面,自噬在某些情况下也可促进炎症反应,自噬相关蛋白和高尔基体重组-堆叠蛋白参与了自噬的促炎效应。以本文简要综述细胞自噬在心血管疾病炎症反应中的作用,探讨自噬与炎症反应的相关分子机制,为心血管疾病中炎症反应的治疗提供新的思路。Autophagy, a highly conserved cell degradation process and a programmed cell death process, can maintain intracellular homeostasis. Cardiovascular diseases are accompanied by inflammatory response and are closely related to autophagy. Recent studies reveal that on one hand, autophagy can protect against inflammation in the cardiovascular system taining mitochondria homeostasis. This effect is related to through removing accumulated protein and mainsuppressing inflammasome and calpain-dependent IL-Io~ activation. On the other hand, autophagy can promote inflammatory reaction under some circumstances. ATG factors and a specialized unconventional secretion regulator Golgi reassembly-stacking protein （GRASP） may be involved in this pro-inflammatory effect. This paper reviews the research progress of autophagy in inflammation of cardiovascular disease and discusses related molecular mechanisms between autophagy and inflammation so as to provide some new insight into the treatment of inflammation in cardiovascular diseases.

关 键 词：细胞自噬 炎症 心血管疾病 

分 类 号：R392.3[医药卫生—免疫学]