治疗前^(18)F-FDGPET/CT最大标准摄取值评估鼻腔NK/T细胞淋巴瘤的预后  

Maximum standard uptake on pretreatment ^(18)F-FDG PET/CT scan in assessment of prognosis of nasal natural killer/T-cell lymphoma

作　　者：丁重阳[1] 孙晋[1] 吴宇霖[1] 李洋洋[1] 杨伟[1] 李天女[1] 

机构地区：[1]南京医科大学第一附属医院核医学科,江苏南京210029

出　　处：《中国医学影像技术》2015年第5期729-732,共4页Chinese Journal of Medical Imaging Technology

基　　金：放射性靶向治疗乳腺癌及骨转移的研究(201303038)

摘　　要：目的探讨18F-FDG PET/CT最大标准摄取值(SUVmax)评估治疗前鼻腔NK/T细胞淋巴瘤患者预后的价值。方法 31例确诊的鼻腔NK/T细胞淋巴瘤患者均于治疗前接受18F-FDG PET/CT检查,患者预后单因素分析采用Kaplan-Meier法,采用Cox模型进行多因素分析。结果 31例鼻腔NK/T细胞淋巴瘤患者治疗前18 F-FDG PET/CT显像中位SUVmax为12.7(4.4~25.7)。单因素分析结果显示,B症状、KPI、治疗模式、SUVmax与鼻腔NK/T细胞淋巴瘤患者的预后相关(P均<0.05);多因素分析显示仅有SUVmax是影响患者预后的独立危险因素(P=0.018)。结论鼻腔NK/T细胞淋巴瘤患者治疗前18F-FDG PET/CT的SUVmax能够预测患者的预后。Objective To explore the prognostic value of maximum standard uptake （SUVmax） of 28 F-FDG PET/CT in assessment of prognosis of newly diagnosed nasal natural killer （NK）/T cell lymphoma patients on pretreatment. Methods The clinical data of 31 patients with nasal NK/T cell lymphoma undergoing 18F-FDG PET/CT scan at pretreatment were analyzed retrospectively. The prognostic factors were analyzed with univariate and multivariate analysis. Results In 31 patients, the median SUVmax on pretreatment lSF-FDG PET/CT was 12.7 （4.4--25.7）. In univariate analysis, B symptoms, KPI, treatment mode and SUVmax were found to be the prognostic factors （all P〈0.05）. Multivariate analysis indicated that only SUVmax was the independent unfavorable prognostic factor （P=0. 018）. Conclusion The SUVmax on pretreatment 18F-FDG PET/CT scan in nasal NK/T cell lymphoma patients can be used to predict the patients prognosis.

关 键 词：鼻肿瘤 淋巴瘤 非霍奇金 18F氟脱氧葡萄糖 预后 

分 类 号：R739.6[医药卫生—肿瘤] R817.4[医药卫生—临床医学]