牙周基础治疗对牙周炎病人血清炎性因子水平及颈动脉内膜中层厚度影响  

EFFECT OF PERIODONTAL NON-SURGICAL TREATMENT ON LEVELS OF SERUM INFLAMMATORY MEDIATORS AND CAROTID INTIMA-MEDIA THICKNESS

作　　者：王崇丽[1] 张继东[1] 廉哲勋[1] 宋宇[2] 吴迎涛 孙品[4] 

机构地区：[1]青岛大学附属医院心内科,山东青岛266003 [2]青岛市市立医院口腔科 [3]青岛市口腔医院牙周病科 [4]青岛大学附属医院心脏超声科

出　　处：《青岛大学医学院学报》2015年第2期181-183,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科技局项目(10-3-4-7-3jch)

摘　　要：目的观察中、重度牙周炎病人牙周基础治疗前后牙周状况、血清炎性因子水平及颈动脉内膜中层厚度的变化,探讨牙周炎与动脉粥样硬化间的关系以及牙周干预治疗对动脉粥样硬化发生发展的影响。方法2012年1月—2013年1月,就诊于青岛市口腔医院的中、重度牙周炎病人100例,随机分为牙周炎治疗组（50例）与牙周炎非治疗组（50例）,并选取40例健康者作为对照组。应用ELISA双抗体夹心法检测牙周治疗前、牙周治疗后12周血清炎性因子C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）及细胞间黏附分子-1（ICAM-1）水平的变化,应用彩色多普勒超声检测研究对象牙周治疗前、牙周治疗后24周颈动脉内膜中层厚度。结果牙周治疗前牙周炎治疗组血清炎性因子水平、颈动脉内膜中层厚度较对照组高,差异均有显著性（t=2.71~5.35,P〈0.05）;牙周炎治疗组牙周干预治疗后血清炎性因子水平及颈动脉内膜中层厚度较牙周炎非治疗组明显降低,差异均有显著性（t=2.18~7.34,P〈0.05）。结论牙周炎与动脉粥样硬化的发生可能有一定的相关性,积极治疗牙周炎可能逆转或延缓动脉粥样硬化的发生发展。Objective To observe the changes of periodontal condition, levels of serum inflammatory mediators and ca- rotid intima-media thickness in moderate and severe chronic periodontitis before and after periodontal non-surgical treatment, and to investigate the association between periodontitis and atherosclerosis and the effect of periodontal intervention on atheroselerosis. Methods From January 2012 to January 2013, 100 patients with moderate or severe periodontitis treated in our hospital were evenly randomized to periodontitis-treatment group and non-surgical-treatment group, and 40 healthy people served as controls. Le- vels of serum inflammatory mediators （CRP, IL-6, TNF-α and ICAM-1） were detected by double antibody sandwich ELISA met- hod, before and 12 weeks after periodontal treatment, and carotid intima media thickness was measured by color Doppler ultra- sonography before and 24 weeks after periodontal treatment. Results Levels of serum inflammatory mediators and carotid inti- ma-media thickness in periodontitis group were higher than that of healthy control group before the periodontal treatment （t = 2.71--5.35,P〈0.05）. After treatment, the levels of serum inflammatory mediators and carotid intima-media thickness in peri- odontitis groups were much lower than that in the non-surgical-treatment group （t=2.18-7.34,P〈0.05）. Conclusion There may be some correlation between periodontitis and atherosclerosis. Active treatment of periodontitis may reverse or delay the occur- rence and development of atherosclerosis.

关 键 词：牙周炎 动脉粥样硬化 C反应蛋白质 白细胞介素6 肿瘤坏死因子α 细胞黏附分子 

分 类 号：R781.42[医药卫生—口腔医学]