宫颈癌介入化疗前后SDF-1和CXCR4表达及意义  

EXPRESSIONS AND SIGNIFICANCE OF SDF-1 AND CXCR4 IN CERVICAL CANCER BEFORE AND AFTER CHEMOTHERAPY

作　　者：程海燕[1] 杨秀凤[1] 马会清[1] 

机构地区：[1]青岛大学医学院第二附属医院妇科,山东青岛266042

出　　处：《齐鲁医学杂志》2015年第2期135-137,140,共4页Medical Journal of Qilu

基　　金：青岛市卫生局资金资助项目(2010-wszd042)

摘　　要：目的探讨宫颈癌介入化疗前后基质细胞衍生因子-1(SDF-1)及其特异性受体CXC趋化因子受体4(CXCR4)蛋白表达变化,以及对预测介入化疗敏感性的作用。方法应用免疫组化方法,测定40例宫颈癌组织介入化疗前后SDF-1、CXCR4蛋白的表达,分析其与介入化疗效果的关系。结果宫颈癌介入化疗临床总有效率为85.0%,介入化疗有效率与临床期别无关(P>0.05)。介入化疗前后宫颈癌组织中SDF-1蛋白的表达差异无显著性(P>0.05),CXCR4蛋白表达差异有显著性(χ2=4.645,P<0.05)。介入化疗前SDF-1阳性及阴性者介入化疗有效率分别为84.0%(21/25)、80.0%(12/15),两者比较差异无显著性(P>0.05);介入化疗前CXCR4阳性者及CXCR4阴性者介入化疗总有效率分别为96.7%(29/30)、70.0%(7/10),两者比较差异有显著性(χ2=6.125,P<0.05)。结论介入化疗能通过改变宫颈癌组织中CXCR4蛋白表达,抑制肿瘤细胞的增殖和浸润;介入化疗前检测宫颈癌组织中CXCR4蛋白的表达可能用于预测介入化疗的临床疗效。Objective To explore the expressions of SDF-1 and CXCR4 in cervical cancer before and after interventional chemotherapy （IC）, and its role in predicting the sensitivity of IC. Methods Expressions of SDF-1 and CXCR4 protein in 40 ca- ses of cervical cancer were detected by immunohistochemistry, before and after IC, and their association with the efficacy of the chemotherapy was evaluated. Results The total clinical efficiency of IC was 85.0%, which was not correlated with clinical sta- ges （P〉0.05）. The difference of expression of SDF-1 before and after IC was not significant （P〉0.05）, but the difference of ex- pression of CXCR4 was significant （X^2=4.645 ,P〈0.05）. Those with positive SDF-1 before IC,the effective rate of chemotherapy was 84% （21/25）3 for those with negative SDF 1 was 80.0% （12/15）, no significant difference was found between them （P〉0.05）. Those with positive CXCR4 before IC,the effective rate was 96.7 ~;and those with negative CXCR4, 70.0% （7/10）, the difference between them was significant （X^2=6.125,P〈0.05）. Conclusion Interventional chemotherapy can inhibit tumor cell proliferation and invasion through changing the expressions of CXCR4 in cervical cancer tissue. Detection of CXCR4 expression before chemotherapy intervention is expected to be used for predicting clinical efficacy of the therapy.

关 键 词：宫颈肿瘤 化学栓塞 治疗性 趋化因子CXCL12 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]