甲状腺透明细胞型滤泡癌2例临床病理分析  

CLEAR-CELL THYROID FOLLICULAR CARCINOMA:A CLINICOPATHOLOGICAL ANALYSIS OF TWO CASES

作　　者：王学丽[1] 王学均 陈青[1] 

机构地区：[1]滨州市中心医院病理科,山东滨州251700

出　　处：《齐鲁医学杂志》2015年第2期152-153,156,共3页Medical Journal of Qilu

摘　　要：目的探讨甲状腺透明细胞型滤泡癌的临床病理特征。方法报道2例甲状腺透明细胞型滤泡癌,结合文献对其临床病理特征进行分析。结果 2例病人均为老年男性,均无意中发现颈前区包块而就诊。光镜下观察：1例肿瘤细胞胞质透明伴显著坏死,侵及周围甲状腺及骨骼肌;1例双侧甲状腺内多发结节,边界清晰,未见甲状腺外侵犯,肿瘤细胞胞质透明,可见充满稀薄黏液的滤泡被纤细的纤维血管分隔成巢片状。免疫组化检查：2例病人甲状腺转录因子1（TTF-1）和甲状腺球蛋白（TG）均阳性,CD10和降钙素（CT）均阴性,Ki-67指数分别为60%~70%和3%~5%。1例随访13个月后出现多处骨转移;1例随访6个月无复发,状况良好。结论甲状腺透明细胞型滤泡癌是甲状腺滤泡癌的一种罕见亚型,预后与肿瘤的侵袭程度密切相关。Objective To study the elinicopathologieal features of clear-cell follicular thyroid carcinoma （CCFTC）. Methods Two cases of CCFTC were reported and analyzed with reference of the literature concerned. Results The two pa- tients were old men who found the mass on anterior region of the neck accidently. Microscopically, transparent cytoplasm with nec- rosis of tumor cells was noted, and surrounding thyroid and skeletal muscle were involved in one case; the other one was seen mul tiple nodules within the thyroid with clear edge, with no involvement beyond the thyroid gland. The tumor cell cytoplasm was transparent, the follicles filling with thin mucus were separated by fiber vascular slender into nest sheets. Immunohistochemically, the TTF-1 and TG were positive, and CD10 and calcitonin negative in the two patients, Ki-67 index was 60%- 70% and 3%-5%, respectively. One with multiple bone metastases after 13 months, and the other one was fine with no recurrence during six months of follow-up. Conclusion CCFTC is a rare subtype of follicular thyroid carcinoma, its prognosis is closely related to the degree of tumor invasion.

关 键 词：甲状腺 腺癌 透明细胞 免疫组织化学 病理学 预后 

分 类 号：R736.1[医药卫生—肿瘤]