度洛西汀并小剂量氨磺必利治疗难治性抑郁症的效果  

EFFICACY OF DULOXETINE COMBINED WITH SMALL-DOSE AMISULPRIDEIN IN THE TREATMENT OF REFRACTORY DEPRESSION

作　　者：梁瑞华[1] 郭艳红[1] 郭庆焕 

机构地区：[1]青岛市精神卫生中心精神科,山东青岛266034 [2]中国人民解放军第401医院干部二科

出　　处：《齐鲁医学杂志》2015年第2期209-210,212,共3页Medical Journal of Qilu

摘　　要：目的探讨度洛西汀并小剂量氨磺必利治疗难治性抑郁症的疗效和安全性。方法难治性抑郁症病人66例,随机分为两组。研究组(33例)采用度洛西汀并氨磺必利治疗,对照组(33例)单用度洛西汀治疗,在治疗前及治疗的第1、2、4、6和8周末分别采用汉密尔顿抑郁量表(HAMD-17)和汉密尔顿焦虑量表(HAMA)评定疗效,采用治疗副反应量表评定不良反应。结果研究组治疗后的第1、2和4周末HAMD、HAMA评分均显著低于对照组,差异有显著性(t=-8.33^-5.44,P<0.05)。研究组的临床有效率高于对照组,差异有显著性(χ2=4.56,P<0.05)。两组主要不良反应比较差异无显著性(P>0.05)。结论度洛西汀并小剂量氨磺必利较单用度洛西汀治疗难治性抑郁症起效更快,不良反应相当。Objective To investigate the clinical efficacy and safety of duloxetine combined with small-dose amisulpridein in the treatment of refractory depression. Methods Sixty patients with refractory depression were evenly randomized to study group and control group.The patients in the study group were treated with duloxetine combined with small-dose amisulpride,those in the control group were given only duloxetine.The efficacy and adverse reactions were assessed in the 1st,2nd,4th,6th and 8th weekends after therapy. Results Scores of HAMD-17 and HAMA in study group were significantly lower than that in the control group in the 1st,2nd and 4th weekends of the treatment（t=-8.33--5.44,P〈0.05）,the effective rate was higher,the difference was significant between the two groups in terms of the efficacy（χ2=4.56,P〈0.05）,but no significant difference between them with regard to adverse reactions（P〉0.05）. Conclusion Duloxetine in combination with small-dose amisulpride may take a more rapid onset of action on refractory depression than using duloxetine only,the adverse reactions are similar.

关 键 词：度洛西汀 氨磺必利 抑郁症 治疗结果 

分 类 号：R749.4[医药卫生—神经病学与精神病学]