PARVB基因rs5764455多态性与青岛汉族人群非酒精性脂肪性肝病遗传易感性的相关性  

Relationship between PARVB rs5764455 polymorphism and non-alcoholic fatty liver disease

作　　者：耿宁[1] 姜曼[1] 王健[1] 刘洋[1] 姜相君[1] 辛永宁[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院,266021

出　　处：《实用医学杂志》2015年第9期1434-1438,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81170337/H0304);青岛市民生科技计划项目(编号:14-2-3-17-nsh)

摘　　要：目的:探讨小细胞蛋白β基因(PARVB基因)rs5764455多态性与青岛汉族人群非酒精性脂肪性肝病(NAFLD)遗传易感性的相关性。方法:收集青岛地区B型超声诊断为NAFLD的患者(NAFLD组,n=230)及排除肝脏相关疾病的健康人群(对照组,n=330)。多聚酶链反应及DNA测序法进行PARVB基因型测定。检测并比较各组人群临床基本信息差异有无统计学意义。计算各组基因型频率、等位基因频率分布及发生NAFLD相对风险。结果:PARVB基因rs5764455位点基因型频率及等位基因频率在NAFLD组与对照组中的分布差异无统计学意义(基因型频率χ2=0.182,P=0.913;等位基因频率χ2=0.180,P=0.672)。校正体质量、BMI等混杂因素前后,C/T+T/T基因型携带者与C/C基因型携带者相比,发生NAFLD的风险度无统计学差异(OR=1.266,P=0.178;校正OR=1.631,P=0.096)。与C/C基因型携带者相比,C/T+T/T基因型携带者体质量、BMI、甘油三酯及ALT、AST升高且差异有统计学意义(P<0.05)。结论 :在青岛汉族人群中,PARVB基因rs5764455多态性与NAFLD不相关。Objective To investigate the association between （beta-parvin） PARVB gene rs5764455 polymorphism and susceptibility to non-alcoholic fatty liver disease （NAFLD）. Methods A total of 230 patients with NAFLD （NAFLD, n = 230） and 230 control subjects （control, n = 330） were genotyped by PCR and direct sequencing. Clinical information was detected and compared in different groups. Genotypic frequency and gene frequency distribution in the two groups and relative risks to NAFLD susceptibility were assessed statistically , respectively. Results No statistical differences were observed between PARVB gene rs5764455 genotypic frequency with gene frequency distribution and the two groups, respectively （Genotypic frequency χ2 = 0.182, P = 0.913; gene frequency χ2 = 0.180, P = 0.672）. Comparing C/T ＋ T/T genotype carrier with C/C genotype carrier, there were no differences concerning the relative risks to NAFLD susceptibility （OR = 1.266, P =0.178;adjusted OR =1.631, P =0.096） before and after adjusting body mass, BMI and so on. In the latter group, there are significant differences in the increases of body mass, BMI, TG, ALT and AST （P 〈0.05）. Conclusion Non-relationship was observed between PARVB gene rs5764455 polymorphism and the risk of NAFLD in Qingdao Han Chinese.

关 键 词：脂肪肝  非酒精性 单核苷酸多态性 PARVB基因 

分 类 号：R575[医药卫生—消化系统]