生物羊膜联合丝裂霉素C在难治性青光眼小梁切除术中应用  

Clinical analysis of biotic amniotic membrane with mitomycin C applied in refractory glaucoma trabeculectomy

作　　者：陈炜江[1] 应洒 

机构地区：[1]嵊州市人民医院,浙江省312400

出　　处：《中国实用眼科杂志》2015年第5期539-541,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的观察生物羊膜联合丝裂霉素C应用于难治性青光眼小梁切除术中的临床疗效。方法采用小梁切除术中联合使用生物羊膜、丝裂霉素C治疗难治性青光眼29例（35只眼），术后随访18个月，观察眼压、滤过泡、视力及并发症情况。结果术后18个月，35只眼中。完全成功77．14％（27／35），条件成功14．29％（5／35），失败8．57％（3／35），成功率为91．43％（32／35）。术后6个月、18个月，功能性滤过泡比率分别为94．29％（33／35）、91．43％（32／35）。术后6个月视力与术前相比有提高，两组间差异有统计学意义（P〈0．05）。术后并发症主要有前房出血、浅前房和低眼压、脉络膜脱离。结论在小梁切除术中联合应用生物羊膜与丝裂霉素C治疗难治性青光眼，具有疗效确切，并发症较少、成功率高等优点。Objective To observe the results of trabeculectomy combined with biotic amniotic membrane （AMT） and mitomycin C （MMC） in the treatment of the refractory glaucoma. Methods About 29 cases （35 eyes） with refractory glaucoma were treated with trabeculectomy combined with biotic amniotic membrane （AMT） and mitomycin C （MMC）. All patients were followed up for 18 months. Postoperative intraocular pressure （IOP）, filtration blebs, visual acuity and complications were observed. Results Eighteen months postoperatively, completely successful 77.14% （27/35）, partly suc- cessful 14.29%（5/35）, failure 8.57% （3/35）, the success rate was 91.43 %（32/35）. The functional filtra- tion blebs took 94.29%（33/35）, 91.43%（32/35） at postoperative 6 months and 18 months. Compared with that at pre-operation, visual acuities improved at 6 postoperative months, there were significant differences （P 〈0.05）. The postoperative complicalions mainly involved hyphema, fiat anterior cham- ber and ocular hypotension, amotiochoroideae. Conclusions Trabeculectomy combined with biotic anmiotic membrane （AMT） and mitomycin C （MMC） is effective for refractory glaucoma, with little complications, and it is worth for popularizing in clinical application.

关 键 词：难治性青光眼 小梁切除 生物羊膜 丝裂霉素 

分 类 号：R775.05[医药卫生—眼科]