女性原发性开角型青光眼发病的危险因素分析  

Study on risk factors for female patients with primary open-angle glaucoma

作　　者：杨庆国[1,2] 王平[1,2] 岳军[1,2] 覃光海[1,2] 王军令[1,2] 龚晋[1,2] 郑娇[1,2] 

机构地区：[1]三峡大学仁和医院眼科 [2]三峡大学眼科研究所,湖北宜昌443001

出　　处：《现代预防医学》2015年第10期1910-1913,共4页Modern Preventive Medicine

摘　　要：目的探讨女性原发性开角型青光眼（POAG）发病的主要危险因素。方法采用问卷调查的方式收集研究118例女性POAG患者及对照人群的一般资料及相关信息,分析女性POAG患者的危险因素。结果绝经年龄≥50岁（OR=0.402,95%CI：0.240～0.673,P〈0.05）是女性POAG发病的保护因素;高血压（OR=2.213,95%CI：1.322～3.712,P〈0.05）、高度近视（OR=3.893,95%CI：2.319～6.535,P〈0.05）、一级亲属有青光眼家族史（OR=8.954,95%CI：1.783～45.128,P〈0.05）是女性POAG发病的独立危险因素。结论高血压、高度近视、一级亲属有青光眼家族史是女性POAG的重要危险因素,而女性雌激素可能是女性POAG的保护因素。Objective The aim of this study was to explore the risk factors for female patients with primary open-angle glaucoma.Methods The charts of 118 female patients diagnosed with primary open-angle glaucoma and treated in Renhe hospital of three gorges university were reviewed. Non-POAG patients over the same period were collected as the control group. A questionnaire survey was used to collect general information and related risk factors. Multivariate logistic regression analysis was used in screening the risk factors of female primary open-angle glaucoma patients. Results Logistic regression analysis showed that age at menopause≥50 years（OR=0.402, 95%CI： 0.240～0.673, P〈0.05） was a protective factor for women POAG. Hypertension（OR=2.213, 95%CI：1.322～3.712, P〈0.05）, high myopia（OR=3.893, 95%CI： 2.319～6.535, P〈0.05）, having a relative with a family history of glaucoma（OR=8.954, 95%CI： 1.783～45.128, P〈0.05） were the independent risk factors for women POAG. Conclusion Hypertension, high myopia, a family history of glaucoma are important risk factors for female POAG patients, while the female hormone estrogen may be a protective factor for female POAG.

关 键 词：青光眼 开角型 女性 危险因素 病例对照 

分 类 号：R775[医药卫生—眼科]